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书名 阿米巴性角膜炎诊断与治疗(英文版)(精)
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作者 孙旭光
出版社 人民卫生出版社
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简介
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孙旭光主编的《阿米巴性角膜炎诊断与治疗(英文版)》主要对阿米巴性角膜炎的流行病学、病原菌与发病机理、诊断与鉴别诊断及治疗进行了总结,并介绍了国内相关的资料和个人的临床诊治经验。在阿米巴性角膜炎治疗章节中,著者不仅详细解读了治疗的原则及方案,而且还列出了具体的治疗方法、常用眼部药的药物浓度,以及临时配置眼药的方法。本书的主要读者对象为各级医疗机构的眼科医生、眼科研究生,并且也可作为眼科医生规培的参考书。
目录
1 Epidemiology
1.1 Incidence in Developed Countries and Regions
1.2 Incidence in Developing Countries and Regions
References
2 Etiology
2.1 Biological Characteristics of Free-Living Amoeba
2.2 Acanthamoeba spp
2.2.1 Trophozoite
2.2.2 Cyst
2.2.3 Classification of Acanthamoeba
2.2.4 Genotyping Identification of Acanthamoeba Strains in the Natural Environment
2.3 Naegleria spp
2.3.1 Trophozoite
2.3.2 Cyst
References
3 Pathological Mechanisms and Immunological Reactions
3.1 Pathological Mechanisms
3.1.1 Adhesive Attraction to the Corneal Epithelium
3.1.2 Non-contact Cytolysis Induced by Protease
3.1.3 Contact-Dependent Cytolysis
3.1.4 Apoptosis Mediated by Acanthamoeba
3.1.5 Cytokines
3.2 Immunological Reactions
3.2.1 Non-specific Immunoreaction
3.2.2 Specific Immunoreaction
3.2.3 Preventive Immunoreaction
References
4 Clinical Manifestations
4.1 General Conditions
4.1.1 Distribution Characteristics of Ages
4.1.2 Distribution Characteristics of Genders
4.1.3 Distribution Characteristics of Occupations
4.1.4 Risk Factors
4.1.5 Seasonal Morbidity
4.2 Clinical Symptoms
4.3 Clinical Signs
4.3.1 Early Stage
4.3.2 Advanced Stage
4.3.3 Late Stage
4.4 Coinfection
4.5 Complications
4.5.1 Anterior Uveitis
4.5.2 Intraocular Hypertension or Secondary Glaucoma
4.5.3 Anterior Scleritis
4.5.4 Complicated Cataract
References
5 Diagnosis and Differential Diagnosis
5.1 Diagnosis of Acanthamoeba Keratitis
5.1.1 Clinical Diagnosis
5.1.2 Etiological Diagnosis
5.2 Differential Diagnosis of Acanthamoeba Keratitis
5.2.1 Key Points for Differential Diagnosis of Acanthamoeba Keratitis from Viral Keratitis
5.2.2 Key Points of Differential Diagnosis of Acanthamoeba Keratitis from Fungal Keratitis
5.2.3 Key Points of Differential Diagnosis of Acanthamoeba Keratitis froln Bacterial Keratitis
References
6 Laboratory Examination
6.1 Method of the Cornea Sample Collection
6.1.1 Sample Collection for the Cornea Smear
Cytology Examination
6.1.2 Sample Collection for the Culture of Acanthamoeba
6.2 Conventional Methods of Examination
6.2.1 Smear Cytological Examination of the Corneal Scraping
6.2.2 Cultivation of Acanthamoeba
6.2.3 Test of In Vitro Susceptibility to Acanthamoeba
6.2.4 Histopathological Examination
6.2.5 Flagellation Test
6.3 Special Examination Methods
6.3.1 Special Staining Methods
6.3.2 Electron Microscope Examination
6.3.3 Molecular Biology Examination
References
7 Treatment ofAcanthamoeba Keratitis
7.1 Anti-amoebic Drugs
7.1.1 Aromatic Diamidines
7.1.2 Cationic Biguanide Disinfectants
7.1.3 Imidazoles
7.1.4 Aminoglycosides
7.1.5 Drug Susceptibility
7.1.6 Effect of Glucocorticoids
7.1.7 Novel Anti-amoebic Drugs Investigated
7.2 Clinical Therapeutic Principles and Regimens
7.2.1 Therapeutic Principles
7.2.2 Therapeutic Regimens
7.3 Surgical Management
7.3.1 Debridement and Cautery of the Corneal Ulcer
7.3.2 Excision of Necrotic Tissues of the Corneal Lesions and Amniotic Membrane Transplantation
7.3.3 Corneal Transplantation
7.4 Typical Case Reports
7.4.1 Case 1 : Bilateral Acanthamoeba Keratitis Related to Orthokeratology
7.4.2 Case 2: Acanthamoeba Keratitis Related to Vegetant Trauma
7.4.3 Case 3: Acanthamoeba Keratitis Coinfected with Fungal Infection
7.4.4 Case 4: Acanthamoeba Keratitis Caused by a Splashed Insect
7.4.5 Case 5: Acanthamoeba Keratitis Related to Orthokeratology
7.5 Dispensing Method of Anti-amoebic Eye Drops in Hospital
References
Index
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