Preface
Acknowledgements
Notes on using The Maudsley Prescribing Guidelines
List of abbreviations
Chapter 1 Plasma level monitoring of psychotropic drugs
Interpreting sample results
Acting on clozapine plasma concentration results
Interpreting post-mortem blood concentrations
Chapter 2 Schizophrenia
ANTIPSYCHOTIC DRUGS
General introduction
General principles of prescribing
Minimum effective doses
Quick reference for licensed maximum doses
Equivalent doses
High‐dose antipsychotics: prescribing and monitoring
Antipsychotic prophylaxis
Combined antipsychotics
Negative symptoms
Monitoring
Relative adverse effects – a rough guide
Treatment algorithms for schizophrenia
First‐generation antipsychotics–place in therapy
Omega‐3 fatty acid (fish oils) in schizophrenia
New and developing drugs to treat schizophrenia
NICE guidelines for the treatment of schizophrenia
Antipsychotic response – to increase the dose, to switch,to add or just wait – what is the right move?
Antipsychotic long‐acting injections
Depot antipsychotics – pharmacokinetics
Management of patients on long‐term depots
Aripiprazole LAI
Olanzapine LAI
Paliperidone palmitate LAI
Risperidone LAI
ANTIPSYCHOT ICS – ADVERS E EFFECTS
Extrapyramidal side‐effects
Akathisia
Weight gain
Treatment of drug‐induced weight gain
Tardive dyskinesia
Neuroleptic malignant syndrome
Catatonia
QT prolongation
Dyslipidaemia
Diabetes and impaired glucose tolerance
Hypertension
Hyponatraemia
Hyperprolactinaemia
Sexual dysfunction
Pneumonia
Switching antipsychotics
REFRACTORY SCHIZOPHRENIA AND CLOZAPINE
Clozapine – dosing regimen
Optimising clozapine treatment
Alternatives to clozapine
Re‐starting clozapine after a break in treatment
Initiation of clozapine for community‐based patients
CLOZAPINE – ADVERS E EFFECTS
Common adverse effects
Clozapine: uncommon or unusual adverse effects
Clozapine: serious haematological and cardiovascular adverse effects
Clozapine‐induced hypersalivation
Clozapine‐induced gastrointestinal hypomotility (CIGH)
Clozapine, neutropenia and lithium
Clozapine and chemotherapy
Chapter 3 Bipolar affective disorder
Lithium
Valproate
Carbamazepine
Antipsychotics in bipolar disorder
Treatment of acute mania or hypomania
Bipolar depression
Rapid‐cycling bipolar affective disorder
Prophylaxis in bipolar affective disorder
Physical monitoring for people with bipolar affective disorder
Chapter 4 Depression and anxiety
Introduction
Basic principles of prescribing in depression
Official guidance on the treatment of depression
Antidepressants: general overview
St John’s wort
Recognised minimum effective doses of antidepressants
Drug treatment of depression
Treatment of refractory depression
Psychotic depression
Electroconvulsive therapy and psychotropic drugs
Psychostimulants in depression
Post‐stroke depression
Treatment of depression in the elderly
Antidepressant discontinuation symptoms
Antidepressant prophylaxis
Antidepressants: alternative routes of administration
Antidepressants: swapping and stopping
Drug interactions with antidepressants
Cardiac effects of antidepressants
Antidepressant‐induced arrhythmia
Antidepressant‐induced hyponatraemia
Antidepressants and hyperprolactinaemia
Antidepressants and diabetes mellitus
Antidepressants and sexual dysfunction
SSRIs and bleeding
Antidepressants: relative adverse effects – a rough guide
Anxiety spectrum disorders
Benzodiazepines in the treatment of psychiatric disorders
Benzodiazepines: dependence and detoxification
Benzodiazepines and disinhibition
Chapter 5 Children and adolescents
Principles of prescribing practice in childhood and adolescence
Depression in children and adolescents
Bipolar illness in

一本为精神疾病患者开具精神科处方药物的参考书。本书被广泛使用，涵盖专业人士需了解的各种相关信息。包括如何开具处方、需要注意的不良反应、如何有效增强药效或更换药物，例如抗精神病药、抗抑郁药和抗焦虑药。初级专业人士通过阅读本书将获得精神疾病用药的基础理论、安全性和疗效方面的重要信息。经验丰富的临床医生将会从本书在他们可能不会经常遇到的更复杂的问题上找到很好的指导。

第12版基于过往数据回顾和近期临床实践，提供了简单但详细的精神疾病和相关精神药理学的综述。主要介绍血浆药物水平监测、精神分裂症、双向情感障碍、抑郁症、焦虑症、儿童和青少年用药、药物滥用，以及特殊患者群体用药。每部分都有完整的参考文献，以便在需要时可以快速查询证据库。本书还介绍了尚未得到共识的药物治疗，以及药物与乙醇、烟碱和咖啡因的相互作用等方面的内容。