《中国医学院士文库》从文化出版与医疗卫生这两个行业的结合点上，准确地把握住了军地医务人员对弘扬医德医风、提升医疗技术的深层需求和期待，广大医务人员可以从中领略、学习到我国医学界名医大家不畏艰辛的奋斗历程、科学严谨的治学风范、勇于创新的学术精神、开阔深刻的思维品质。

《侯凡凡院士集(精)》作为丛书之一，充分诠释了侯凡凡院士的学术成就、学术思想和学术风范，可供广大医学工作者学习、借鉴。

《侯凡凡院士集》是《中国医学院士文库》的分册之一。本书由六部分组成。第一部分奋斗历程，介绍了院士的主要经历和事业发展的宝贵经验；第二部分学术贡献，包括院士的主要学术论文、学术著作以及学术年表等，反映了院士在理论创新和技术进步方面的主要成果及其价值；第三部分治学之道，阐述了院士的创新意识、严谨作风和刻苦精神；第四部分大师风范，记载了院士在培养人才和团队建设上为人师表的生动事例；第五部分社会影响，汇集了社会各界对院士学术成果和先进事迹的评价和赞誉；第六部分人生风采，以丰富的图片资料展示了院士在不同时期工作、讲学、国际交流、社会活动和业余生活等方方面面的风采。全书充分诠释了侯凡凡院士的学术成就、学术思想和学术风范，可供广大医学工作者，特别是从事肾病临床、科研、教学的专业人员学习、借鉴。

第一部分 奋斗历程

 侯凡凡院士简历

第二部分 学术贡献

 一、侯凡凡院士的学术成就与学术思想

 二、侯凡凡院士的主要学术论文

 (一)临床研究论文

 Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency

 Renoprotection of Optimal Antiproteinuric Doses(ROAD)Study: A Randomized

Controlled Study of Benazepril and Losartan in Chronic Renal Insufficiency

 Urinary Angiotensinogen Level Predicts Acute Kidney Injury in Acute

Decompensated Heart Failure: a Prospective，Two-Stage Study

 Enhanced Expression of Receptor for Advanced Glycation End Products in

Chronic Kidney Disease

 Receptor for Advanced Glycation End Products on Human Synovial Fibroblasts:

Role in the Pathogenesis of Dialysis-Related Amyloidosis

 Accumulation of Tissue Advanced Glycation End Products Correlated with

Glucose Exposure Dose and Associated with Cardiovascular Morbidity in

Patients on Peritoneal Dialysis

 Renal Expression of Advanced Oxidative Protein Products Predicts Progression

of Renal Fibrosis in Patients with IgA Nephropathy

 Metabolic Syndrome，but Not Insulin Resistance，is Associated with an

Increased Risk of Renal Function Decline

 High Level of Proteinuria During Treatment With Renin--Angiotensin Inhibitors

Is A Strong Predictor of Renal Outcome in Nondiabetic Kidney Disease

 Successful Treatment of Massive Ascites with Intraperitoneal Administration of

a Steroid in a Case of Systemic Lupus Erythematosus

 Increased Plasma Advanced Oxidation Protein Products is an Early Marker of

Endothelial Dysfunction in Type 2 Diabetes Patients Without Albuminuria

 (二)基础研究论文

 Kindlin-2 Mediates Activation of TGF-β／Smad Signaling and Renal Fibrosis

 A Salt-Induced Reno-Cerebral Reflex Activates RAS and Promotes CKD

Progression

 GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively

Inhibiting TGF-l?-Induced Smad3 Phosphorylation

Advanced Oxidation Protein Products Accelerate Renal Fibrosis in A Remnant

Kidney Model

 Aminoguanidine Inhibits Advanced Glycation End Products Formation on

β2-Microglobulin

 The Receptor of Advanced Glycation End Products Plays A Central Role In

Advanced Oxidation Protein Products-Induced Podoeyte Apoptosis

 Accumulation of Advanced Oxidation Protein Products Induces Podocyte

 Apoptosis and Deletion Through NADPH-Dependent Mechanisms

 Restricted Intake of Dietary Advanced Glycation End Products Retards Renal

Progression in the Remnant Kidney Model

 β2-Microglobulin Modified with Advanced Glycation End Products Delays

Monocyte Apoptosis

 β2-Microglobulin Modified with Advanced Glycation End Products Modulates

Collagen Synthesis by Human Fibroblasts

 Interaction Between β2-Microglobulin and Advanced Glycation End Products

in the Development of Dialysis Related-Amyloidosis

 Advanced Oxidation Protein Products Activate Intrarenal Renin-Angiotensin

System Via a CD36-Mediated，Redox-Dependent Pathway

 Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via

a RAGE-Mediated Signaling Pathway

 Picrorhiza Scrophulariiflora Improves Accelerated Atherosclerosis Through

Inhibition of Redox-Sensitive Inflammation

 Lingzhiols，Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and

Sdective Inhibitors of p-Smad3 from Ganoderma luddum

 Acortatarins A and B，Two Novel Antioxidative Spiroalkaloids with A Naturally

Unusual Morpholine Motif from Acorus Tatarinowii

 Advanced Oxidation Protein Products Accelerate Atherosclerosis Through

Promoting Oxidative Stress and Inflammation

 AGE-LDL Activates Toll Like Receptor 4 Pathway and Promotes Inflammatory

  Cytokines Production in Renal Tubular Epithelial Cells。

 Salt-Induced Changes in Cardiac Phosphoproteome in a Rat Model of Chronic

Renal Failure

 Albumin Overload Activates Intrarenal Renin-Angiotensin System Through

Protein Kinase C and NADPH Oxidasedependent Pathway

 Bioactive Compounds from the Aerial Parts of Brachystemma Calycinum and

Structural Revision of An Octacyclopeptide

 Detection of Advanced Oxidation Protein Products in Patients with Chronic Kidney

Disease by A Novel Monoclonal Antibody

 Vascular Insulin Resistance Related to Endoplasmic Reticulum Stress in

Aortas from a Rat Model of Chronic Kidney Disease

 Advanced Oxidation Protein Products Inhibit Differentiation and Activate

Inflammation in 3T3-L1 Preadipocytes

 Advanced Oxidation Protein Products Induce Inflammatory Response and

Insulin Resistance in Cultured Adipocytes Via Induction of Endoplasmic

Reticulum Stress

 Asymmetrical Dimethylarginine Triggers Lipolysis and Inflammatory Response

Via Induction of Endoplasmic Reticulum Stress in Cultured Adipocytes

 Advanced Oxidation Protein Products Induce Mesangial Cell Perturbation

Through PKC-Dependent Activation of NADPH Oxidase。

 Ethanol Extraction of Picrorhiza Scrophulariiflora Prevents Renal Injury in

Experimental Diabetes Via Anti-Inflammation Action

 Advanced Oxidation Protein Products Promote Inflammation in Diabetic Kidney

 through Activation of Renal Nicotinamide Adenine Dinucleotide Phosphate

Oxidase

 1,25-Dihydroxyvitamin D Improved the Free Fatty-Acid-Induced Insulin

Resistance in Cultured C2C12 Cells

 Phenotypic and Functional Characteristics of Macrophage-Like Cells

Differentiated in Pro-Inflammatory Cytokine-Containing Cultures

 三、侯凡凡院士学术年表

侯凡凡院士在SCI收录期刊发表的社论和特邀述评

侯凡凡院士在SCI收录期刊发表的共同作者论著

侯凡凡院士承担的主要科研项目目录

侯凡凡院士主要国际会议演讲目录

第三部分 治学之道

努力作科学而不是努力作文章

凡凡女人心，不凡医者仁心路

漫漫行医路浓浓鱼水情

循证医学可显著提高医疗卫生活动效率

第四部分 大师风范

医者仁心 师者爱心 学者恒心——记侯凡凡院士

第五部分 社会影响

不凡医者仁心路

最是那昂首的妩媚

走近女院士——侯凡凡

与病人交心才能确保治疗效果

我不认为我是大器晚成

既然当了医生，就得当位好医生

南方医院侯凡凡院士入选“全国医患和谐典型人物”

当医生就要把心交给患者

南方医院《关于开展向侯凡凡同志学习的决定》

病房没有关门，我就不能走远

技高为师 身正为范

第六部分 人生风采

成长经历

医疗科研

国际交流

历史时刻

幸福生活