本书根据作者科研团队的研究基础及成果，系统介绍了矿化胶原作为骨修复材料的提出、研究进展及实际应用。全书包括五章。第一章为天然骨组织及其仿生的综述；第二章为仿生矿化胶原的制备及表征介绍；第三章为仿生矿化胶原的生物相容性和生物活性评价；第四章为仿生矿化胶原修复效果的动物实验评价；第五章为仿生矿化胶原的临床应用实例。
本书不仅适合生物材料领域的研究人员和技术人员阅读，也可作为高等院校相关专业研究生的参考书。

List of Contributors
Preface
1.Natural Bone Tissue and Its Biomimetic Zhi-Ye Qiu, Yun Cui and Xiu-Mei Wang
1.1 Natural Bone Composition and Hierarchical Structure
1.1.1 Bone Composition
1.1.2 Bone Structure
1.2 Natural Bone Formation Patterns and Bone Repair
1.2.1 Bone Generation Model
1.2.2 Fracture Healing and Bone Remodeling
1.3 Bone Defect Repair Materials
1.3.1 Bone Tissue Engineering
1.3.2 Bone Defect Repair Materials
References
2.Preparation and Characterization of Biomimetic Mineralized Collagen Yun Cui, Helen Cui and Xiu-Mei Wang
2.1 The Basic Principles of Biomineralization
2.1.1 Biological Mineralization Interface Control
2.1.2 Natural Bone Formation and Mineralization
2.2 Bionic Mineralization Research
2.2.1 Hierarchical Structure
2.2.2 Prebuilt
2.2.3 Highly Ordered Self-assembly
2.3 Multilevel Process
2.3.1 Ball
2.3.2 Construction Phase
2.4 Mineralized Collagen Nanofibers Multilevel Self-assembly and its Application in the Regeneration of Bone Engineering
2.4.1 Transmission Electron Microscopy
2.4.2 Scanning Electron Microscopy
2.4.3 Crystal Structure
2.5 High-Strength Mineralized Collagen Artificial Bone
2.5.1 General Observation and Density Measurements
2.5.2 High-Strength Mineralized Collagen of Phase
2.5.3 High-Strength Mineralized Collagen Molecular Structure
2.5.4 The Microstructure of High-Strength Mineralized Collagen
2.5.5 Mechanical Properties
2.5.6 In Vitro Biocompatibility
2.5.7 In Vivo Biocompatibility and Stability Evaluations
2.6 Common Market Mineralized Collagen Material
References
3.Biomimetic Mineralized Collagen Biocompatibility Zi-Rui Wang, Yun Cui and Zhi-Ye Qiu
3.1 Cell Response to the Material
3.1.1 Cell Adhesion
3.1.2 Cell Migration
3.1.3 Cell Proliferation and Differentiation
3.1.4 Cell Aggregation
3.1.5 Cell Function
3.2 Biomineralized Collagen Cell Experiments
3.2.1 The Effect of Mineralized Collagen Material and Bone Marrow Mesenchymal Stem Cells Cultured on the Cel Phenotype
3.2.2 Genetic Toxicity of Mineralized Collagen and its Effect on Cultured Cells In Vitro
3.3 The Experimental Evaluation of the Osteoclasts of Mineralized Collagen
3.3.1 Osteogenic Differentiation Gene Expression Profiling of Human Mesenchymal Stem Cells on Hydroxyapatite and Mineralized Collagen
3.3.2 Effects of Mineralized Collagen on Osteoblastic Differentiation of Bone Marrow Stromal Stem Cells Induced by Platelet-Rich Plasma
3.3.3 The Observed Difference of RAW264.7 Macrophage Phenotype on Mineralized Collagen and Hydroxyapatite
3.4 Biological Evaluation
References
4.Assessing the Effect of Mineralized Collagen Based Materials by Animal Experimentation Wei Ai, Yan-Li Hu, Zhi-Min He, Tian-Xi Song and Zi-Rui Wang
4.1 Segmental Bone Defects Repair in Rabbit Radius Model
4.1.1 Objective
4.1.2 Experimental Method
4.1.3 Experiment Result
4.1.4 Discussion
4.1.5 Conclusion
4.2 Bone Void Filling on Femoral Condyle Defect Model in New Zealand White Rabbit
4.2.1 Objective
4.2.2 Study Method
4.2.3 Results and Discussions
4.2.4 Discussion
4.2.5 Conclusions
4.3 Lumbar Intertransverse Process Spinal Fusion in Rabbits Objective
4.3.2 Study Design
4.3.3 Result
4.3.4 Discussion
4.3.5 Conclusion
4.4 Posterolateral Spinal Fusion in Rabbit Model
4.4.1 Objective
4.4.2 Study Design
4.4.3 Results
4.4.4 Conclusions
4.5 The Bone Repairing Capability of Calvarial Defects in Rats
4.5.1 Experiment Purpose
4.5.2 Testing Method
4.5.3 Experimental Results
4.5.4 Discussion
4.5.5 Conclusion
4.6 Cranial Bone Regeneration in Developing Sheep
4.6.1 Experiment Purpose
4.6.2 Testing Method
4.6.3 Experimenta