本书是双语教材，总结多年教学中沉淀的经验，按照医学各专业的特点，将生物化学划分为生物大分子的结构与功能、物质代谢、基因表达和专题篇4个部分，努力构建系统化课程，从学生兴趣、认知规律和探究方便出发合理设计教材的结构，注意联系实际，适度扩大学生的知识面和应用能力，突出教材中知识结构的科学化。并以鲜活灵动的色彩、图文并茂的版面、熟悉的例子吸引刚入门的医学生，让学生感受课程学习的趣味性和挑战性，将是一系统性强、可读性强、深受学生喜爱的教材。

PART Ⅰ : STRUCTURE AND FUNCTION OF BIOMACROMOLECULE

Chapter 1 Structure and Function of Protein

 SECTION 1 THE COMPOSITION OF PROTEIN

1.1 Amino acid

1.2 Peptide

1.3 Some small polypeptides have biological activity

 SECTION 2 MOLECULAR STRUCTURE OF PROTEINS

2.1 Primary structure

2.2 Secondary structure

2.3 Tertiary structure

2.4 Major noncovalent bond

2.5 Quaternary structure

 SECTION 3 RELATION BETWEEN STRUCTURE AND FUNCTION OF PROTEINS

3.1 Primary structure and potential function of protein

3.2 Spatial structure shows the function of protein

 SECTION 4 CHEMICAL AND PHYSICAL PROPERTIES OF PROTEINS

4.1 Ultraviolet absorption spectrum of protein

4.2 Isoelectric point (pI)

4.3 Denaturation of protein

 SECTION 5 ISOLATION, PURIFICATION AND SEQUENCING OF PROTEINS

5.1 Dialysis and ultrafiltration

5.2 Precipitation with acetone, salting precipitation and immunoprecipitation

5.3 Chromatographic separations

5.4 Electrophoresis

5.5 Ultracentrifugation

SUMMARY

Chapter 2 Chemistry of Nucleic Acids

 SECTION 1 MOLECULAR COMPOSITION OF NUCLEIC ACIDS

1.1 Basic components

1.2 Nucleosides

1.3 Mononucleotides

 SECTION 2 MOLECULAR STRUCTURES OF DNA

2.1 Primary structure of nucleic acid

2.2 Chargaff's rules

2.3 Secondary structure of DNA

 SECTION 3 PHYSICO-CHEMICAL PROPERTIES OF NUCLEIC ACIDS

3.1 Viscosity

3.2 Ultraviolet absorption

3.3 Denaturation and renaturation of DNA

3.4 Hydrolysis of acid or alkali

 SECTION 4 STRUCTURES OF RNA

4.1 Messenger RNA

4.2 Transfer RNA

4.3 Ribosomal RNA

SUMMARY

Chapter 3 Enzymes

 SECTION 1 THE MOLECULAR COMPOSITION AND FUNCTION OF ENZYMES

1.1 The molecular composition of enzymes

1.2 The active center of enzymes

1.3 Many enzymes require cofactors

 SECTION 2 PROPERTIES AND MECHANISM OF ENZYME CATALYSIS

2.1 Remarkable properties of enzymes

2.2 Mechanism of enzyme catalysis

 SECTION 3 THE KINETICS OF ENZYME CATALYSIS

3.1 Catalysis occurs at the active site

3.2 Multiple factors affect the rates of enzyme-catalyzed reactions

3.3 Initial rate is proportionate to enzyme concentration

3.4 Substrate concentration affects reaction rate

3.5 The Michaelis-Menten equations model the effects of substrate concentration

3.6 Kinetic analysis distinguishes competitive from noncompetitive inhibition

 SECTION 4 ZYMOGENS AND ISOZYMES

4.1 Zymogens and zymogen activation

4.2 Isozymes are physically distinct forms of the same catalytic activity

 ……