通过《定量生理学(英文版)》的学习，使同学们建立起通过科学和技术方法解决生物、医学问题的理念，将工程科学的原理和方法与生命科学的原理和方法相结合，认识生命运动的规律，了解掌握对生理分系统具有一定普遍意义的基础内容，并能够分析生理分系统的一些具体问题。

Part I Applied Methodology
1 Introduction to Quantitative Physiology
1.1 Understanding Physiology
1.2 Towards Quantitative Science
1.3 From Genome to Physiome
1.4 Dealing with Complexity
1.5 Why It Is Timely to Study Quantitative Physiology
1.5.1 Multi-Omic Revolution in Biology
1.5.2 Big Data and Personalised Medicine
1.5.3 Genetic Editing and Synthetic Biology
1.6 Questions
References
2 Systems and Modelling
2.1 Modelling Process
2.2 Physiological Organ Systems
2.3 Equation Models
2.4 Using ODEs in Modelling Physiology
2.4.1 Modelling Oscillations
2.4.2 Linear Stability Analysis
2.4.3 Solving ODEs with the g-Function
2.5 Conservation Laws in Physiology
2.5.1 Conservation of Momentum and Energy
2.5.2 Boxing With and Without Gloves
2.5.3 Rotational Movement
2.6 Questions
References
3 Introduction to Basic Modelling
3.1 Building a Simple Mathematical Model
3.1.1 Model of Falling Flea
3.1.2 Scaling Arguments
3.1.3 Example: How High Can an Animal Jump
3.1.4 Example: How Fast Can we Walk before Breaking into a Run
3.2 Models that Involve Metabolic Rate
3.2.1 Modelling Metabolic Rate
3.2.2 Example: Why do Large Birds find it Harder to Fly
3.2.3 Ludwig von Bertalanffy's Growth Model
3.3 Questions
Reference
4 Modelling Resources
4.1 Open Courses
4.2 Modelling Software
4.3 Model Repositories
4.4 Questions
References
Part H Basic Case Studies
5 Modelling Gene Expression
5.1 Modelling Transcriptional Regulation and Simple Networks
5.1.1 Basic Notions and Equations
5.1.2 Equations for Transcriptional Regulation
5.1.3 Examples of Some Common Genetic Networks
5.2 Simultaneous Regulation by Inhibition and Activation
5.3 Autorepressor with Delay
5.4 Bistable Genetic Switch
5.5 Questions
References
6 Metabolic Network
6.1 Metabolism and Network
6.2 Constructing Metabolic Network
6.3 Flux Balance Analysis
6.4 Myocardial Metabolic Network
6.5 Questions
References
7 Calcium Signalling
7.1 Functions of Calcium
7.2 Calcium Oscillations
7.3 Calcium Waves
7.4 Questions
References
8 Modelling Neural Activity
8.1 Introduction to Brain Research
8.2 The Hodgkin-Huxley Model of Neuron Firing
8.3 The FitzHugh-Nagumo Model: A Model of the HH Model
8.3.1 Analysis of Phase Plane with Case Ia
8.3.2 Case Ia > 0 and Conditions to Observe a Limit Cycle
8.4 Questions
References
9 Blood Dynamics
9.1 Blood Hydrodynamics
9.1.1 Basic Equations
9.1.2 Poiseuille's Law
9.2 Properties of Blood and ESR
9.3 Elasticity of Blood Vessels
9.4 The Pulse Wave
9.5 Bernoulli's Equation and What Happened to Arturo Toscanini in 1954
9.6 The Korotkoff Sounds
9.7 Questions
Reference
10 Bone and Body Mechanics
10.1 Elastic Deformations and the Hooke's Law
10.2 Why Long Bones are Hollow or Bending of Bones
10.3 Viscoelasticity of Bones
10.4 Questions
Reference
Part IH Complex Applications
11 Constructive Effects of Noise
11.1 Influence of Stochasticity
11.2 Review of Noise-Induced Effects
11.3 New Mechanisms of Noise-Induced Effects
11.4 Noise-Induced Effects
11.4.1 Stochastic Resonance in Bone Remodelling as a Tool to Prevent
Bone Loss in Osteopenic Conditions
11.4.2 Transitions in the Presence of Additive Noise and On-Off
Intermittency
11.4.3 Phase Transitions Induced by Additive Noise
11.4.4 Noise-Induced Excitability
11.5 Doubly Stochastic Effects
11.5.1 Doubly Stochastic Resonance
11.5.2 A Simple Electronic Circuit Model for Doubly Stochastic
Resonance
11.5.3 Doubly Stochastic Coherence: Periodicity via Noise-Induced
Symmetry in Bistable Neural Models
11.6 New Effects in Noise-Induced Propagation
11.6.1 Noise-Induced Propagation in Monostable Medi