《中国医学院士文库》从文化出版与医疗卫生这两个行业的结合点上，准确地把握住了军地医务人员对弘扬医德医风、提升医疗技术的深层需求和期待，广大医务人员可以从中领略、学习到我国医学界名医大家不畏艰辛的奋斗历程、科学严谨的治学风范、勇于创新的学术精神、开阔深刻的思维品质。

《周宏灏院士集(精)》作为丛书之一，充分诠释了周宏灏院士的学术成就、学术思想和学术风范，可供广大医学工作者学习、借鉴。

《周宏灏院士集》是《中国医学院士文库》的分册之一。本书由六部分组成。第一部分奋斗历程，介绍了院士的主要经历和事业发展的宝贵经验；第二部分学术贡献，包括院士的主要学术论文、学术著作以及学术年表等，反映了院士在理论创新和技术进步方面的主要成果及其价值；第三部分治学之道，阐述了院士的创新意识、严谨作风和刻苦精神；第四部分大师风范，记载了院士在培养人才和团队建设上为人师表的生动事例；第五部分社会影响，汇集了社会各界对院士学术成果和先进事迹的评价和赞誉；第六部分人生风采，以丰富的图片资料展示了院士在不同时期工作、讲学、国际交流、社会活动和业余生活等方方面面的风采。全书充分诠释了周宏灏院士的学术成就、学术思想和学术风范，可供广大医学工作者，特别是从事遗传药理学临床、科研、教学的专业人员学习、借鉴。

第一部分 奋斗历程

 中国遗传药理学的开拓者——记中国工程院院士周宏灏

第二部分 学术贡献

 一、周宏灏院士的学术成就与学术思想

 二、周宏灏院士的主要学术论文

Single-Dose Pharmacokinetics of Ceftriaxone in Healthy Chinese Adults

Racial Differences in Drug Response——Altered Sensitivity to and Clearance of Propranolol

in Men of Chinese Descent as Compared with American Whites

Interindividual Differences in β-receptor Density Contribute to Variability in Response

to β-adrenoceptor Antagonists

Induction of Polymorphic 4'-hydroxylation of S-mephenytoin by Rifampicin

Quinidine Reduces Clearance of(+)-Propranolol More than(一)-Propranolol Through

Marked Reduction in 4-Hydroxylation

Differences in Plasma Binding of Drugs Between Caucasians and Chinese Subjects

Increased Suppression of Exercise-Induced Increase in Renin by Propranolol in Chinese

Subjects

Lack of Effect of Ageing on the Stereochemical Disposition of Propranolol

Differing Effect of Atropine on Heart Rate in Chinese and White Subjects

Ethnic Differences in Response tO Morphine

Stereoselective Disposition of Carvedilol is Determined by CYP2D6-

The Elimination of Diazepam in Chinese Subjects is Dependent on the Mephenytoin

Oxidation Phenotype

In Vivo Inhibition of CYP2C19 But Not CYP2D6 by Fluvoxamine

Genetic Polymorphisms of Debrisoquine and S-mephenytoin Oxidation Metabolism

in Chinese Populations：a Meta-analysis

Differences in the Incidence of the CYP2C19 Polymorphism Affecting the S-Mephenytoin

Phenotype in Chinese Han and Bai Populations and Identification of a New Rare CYP2C19

Mutant Allele

Evidence for the Effect of Gender on Activity of (S)-Mephenytoin 4'-Hydroxylase

(CYP2C19) in A Chinese Population

Meta-analysis of Phenotype and Genotype of NAT2 Deficiency in Chinese

Populations

The Induction Effect of Rifampicin on Activity of Mephenytoin 4'-hydroxylase Related

to M1 Mutation of CYP2C19 and Gene Dose

Evidence for Involvement of Polymorphic CYP2C19 and 2C9 in the N-demethylation

of Sertraline in Human Liver Microsomes

Effect of the Gene Dosage of CYP2C19 on Diazepam Metabolism in Chinese

Subjects

Phenotypic Polymorphism and Gender-related Differences of CYP1A2 Activity in a

Chinese Population

5-Hydroxylation of Omeprazole by Human Liver Microsomal Fractions from Chinese

Populations Related to CYP2C19 Gene Dose and Individual Ethnieity

Ethnic Differences in Drug Metabolism

Effect of the CYP2C19 Oxidation Polymorphism on Fluoxetine Metabolism in Chinese

Healthy Subjects

Pharmacokinetics of Sertraline in Relation to Genetic Polymorphism of CYP2C19

Plasma Caffeine Metaboite Ratio (17X/137X) in Vivo Associated with G-2964A and

C734A Polymorphisms of Human CYPIA2

O-Dealkylation of Fluoxetine in Relation to CYP2C19 Gene Dose and Involvement

of CYP3A4 in Human Liver Microsomes

Assessment of Cytochrome P450 Activity by a Five-drug Cocktail Approach

The Role of CYP2C19 in Amitriptyline N-demethylation in Chinese Subjects

Inducibility of CYPIA2 by Omeprazole in Vivo Related to the Genetic Polymorphism

of CYP 1A 2

Phenotypic Polymorphism of CYP2A6 Activity in a Chinese Population

Histamine N-methyltransferase Gene Polymorphisms in Chinese and Their Relationship

with Enzyme Activity in Erythrocytes

Isozyme-specific Induction of Low-dose Aspirin on Cytochrome P450 in Healthy

Subjects

Gly389Arg Polymorphism of β1-adrenergic Receptor is Associated with the

Cardiovascular Response to Metoprolol

Pharmacokinetics of Citalopram in Relation to Genetic Polymorphism of CYP2C19

The Distribution and Gender Difference of CYP3A Activity in Chinese Subjects

St John's Wort Induces Both Cytochrome P450 3A4一catalyzed Sulfoxidation and

2C19-dependent Hydroxylation of Omeprazole

liell8Val Genetic Polymorphism of CYP3A4 and Its Effects on Lipid-lowering

Efficacy of Simvastatin in Chinese Hyperlipidemic Patients

Gender Specific Association of CYP2C9’3 with Hyperlipidaemia in Chinese

β1-Adrenergic Receptor Polymorphisms Influence the Response to Metoprolol

Monotherapy in Patients with Essential Hypertension

Effect of SL001B 1 Genetic Polymorphism on the Pharmacokinetics of Nateglinide

Frequency of Genetic Polymorphisms of COX1，GP IIIa and P 2Y1 in a Chinese

Population and Association with Attenuated Response to Aspirin

SLC01B 1 521T→C Functional Genetic Polymorphism and Lipid-lowering Efficacy

of Multiple-dose Pravastatin in Chinese Coronary H eart Disease Patients

The Effect of Herbal Medicine Baicalin on Pharmacokinetics of Rosuvastatin

Substrate of Organic Anion-transporting Polypeptide 181

Hepatic Nuclear Factor l a Inhibitor Ursodeoxycholic Acid Influences Pharmacokinetics

of the Organic Anion Transporting Polypeptide 181 Substrate Rosuvastatin and

Bilirubin

Effects of Ginkgo Biloba Extract on the Pharmacokinetics of Bupropion in H ealthy Volunteers

Plant Polyphenol Curcumin Significantly Affects CYPIA2 and CYP2A6 Activity in

Healthy．Male Chinese Volunteers

Pharmacogenetics of Drugs Withdrawn from the Market-

 三、周宏灏院士的主要学术著作

药理学

Textbook of Pharmacology

Case FilesTM Pharmacology

Pharmacology

遗传药理学(第2版)

 四、周宏灏院士重要学术报告、重要讲话

Ethnic Differences in Drug Response

Pharmacogenetic Research about Natural Medicine Effect of Natural Medicine on CYP450

Ethnic Differences in Drug Metabolism

Genetic Polymorphism of CYP2C19 in Chinese Populations

Pharmacogenetics ant’i Pharmacogenomics in Asian Populations and Impaci on Clinical

Pharmacology

Racial Differences in Drug Response Reflect Differences in Distribution of Polymorphic

Traits

Pharmacogenetic and Pharmacogenomic Research in China

Ethnicity，Genet：ics and Tailored Pharmacotherapy

个体化药物治疗的研究与开发

药物基因组学研究技术成果在药物临床评价中的应用

在临床试验中不能忽视亚洲人群种族差异的基因多态性

药物代谢酶基因多态性与个体化药物治疗

个体化医学的实施与展望

五、周宏灏院士学术年表

周宏灏院士论文目录

周宏灏院士专著目录

周宏灏院士科研与教学成果目录

周宏灏院士获国家发明专利目录

第三部分 治学之道

勤勉严谨做学问 情系祖国育桃李

遗传药理学研究的先行者

善于发现 勇于挑战——访临床药理学家周宏灏院士

中国遗传药理学开拓者周宏灏：立志如山 行道如水

周宏灏：中国个体化用药的“拓荒者”

让患者用药更精确

用药也需“量体裁衣”——访我国著名遗传药理学家周宏灏教授

第四部分 大师风范

 一、感悟、经验与情怀

做人做事做学问

心系学子 桃李芬芳 以德服人从严治学

医学教育不能硬套综合大学管理体制——中国工程院院士周宏灏谈我国医学教育现状与改革

春蚕到死丝方尽，人至期颐亦不休

我的情操

 二、部分学生的代表性论文

Effect of Asymmet ric Dimethylarginine on OsteobIastic Differentiation

Effect of SLCOIB1 Genetic Polymorphism on the Pharmacokinetics of Nateglinide

Evidence for Involvement of Calcitonin Gene-Related Peptide in Nitroglycerin Response

and Association with Mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) Glu504Lys

Polymorphism

Molecular Population Genetics of Human CYP3A Locus. Signatures of Positive

Selection and Implications for Evolutionary Environmental Medicine

Coupling HPLC to on-line, Post-column (bio) Chemical Assays for High-resolution

Screening of Bioactive Compounds from Complex Mixtures

KCNJ 11 Lys23Glu and TCFTL2 rs290487(C/T) Polymorphisms affect Therapeutic

Efficacy of Repaglinide in Chinese Patients with Type 2 Diabetes

Inhibition of the Organic Anion-transporting Polypeptide 1B1 by Quercetin: An

in Vitro and in Vivo Assessment

Effect of eIF3a on Response of Lung Cancer Patients to Platinum-Based Chemotherapy

by Regulating DNA Repair

The Pregnane X Receptor Agonist St John's Wort Has No Effects on the Pharmacokinetics

and Pharmacodynamics of Repaglinide

Effects of Lignans Extracted from Eucornmia Ulmoides and Aldose Reductase Inhibitor

Epalrestat on Hypertensive Vascular Remodeling

ABCC2 Polymorphisms and Haplotype are Associated with Drug Resistance in Chinese

Epileptic Patients

Theragnostics Meets Traditional Chinese Medicine: Rational Prediction of Drug-herb

Interactions

Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small

Cell Lung Cancer (NSCLC) Patients

Protective Effects of Eucommia Lignans Against Hypertensive Renal Injury by

Inhibiting Expression of Aldose Reductase

Translational Regulation of RPA2 Via Internal Ribosomal Entry Site and by eIF3a

Effect of NR3C2 Genetic Polymorphisms on the Blood Pressure Response to Enalapril

Treatment

The KCNH2 Genetic Polymorphism (1956, C＞T) Is a Novel Biomarker That Is Associated

with CCB and α, β-ADR Blocker Response in EH Patients in China

Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan

Current Pharmacogenomic Studies on hERG Potassium Channels

Deficiency of Multidrug and Toxin Extrusion 1 Enhances Renal Accumulation of

Paraquat and Deteriorates Kidney Injury in Mice

Effects of the PerOXisome Proliferator Activatedl Receptor-γ Coactivator-la (PGC-la)

Thr394Thr and Gly482Ser Polymorphisms on Rosiglitazone Response in Chinese

Patients with Type 2 Diabetes Mellitus

Characterization and Analyses of Multidrug Resistance-associated Protein 1(MRP1／

ABCC1) Polyrnorphisms in Chinese Population

第五部分 社会影响

我学者首次发现不同种族对药物的差异性

Effectiveness of Drugs May be Influenceol by Racial and Ethnic History

深入了解中国人的心脏

种族与药物的治疗效应

β-受体阻滞药效应呈现种族差异

药物效应的种族差异

我国医学科技占世界之首成果巡礼

Biolnedicine

DNA Chips Bring Personalizeol Medicine to China

开拓国际临床药理新领域——记中国工程院院士周宏灏

世界首张个体化用药基因芯片初步研制成功

个体化用药成为焦点

用多少药，问问你的遗传基因

基因芯片：有助于药物治疗个体化

用药也可“量体裁衣”

周宏灏教授当选世界药理学联合会药物代谢学会理事

省儿童医院聘请周宏灏为终身首席科学家

引领人类个体化用药新时代的人——记我国著名临床与遗传药理学家周宏灏教授

研发一体化做强湖南医药产业——访中国遗传药理学专家、中南大学临床药理研究所

所长、中国工程院院士周宏灏教授

种族差异、遗传及个体化药物治疗

第六部分 人生风采

成长历程

教书育人

学术交流

珍贵合影

人文情怀