FGF是多基因家族，各成员之间具有一定的序列同源性和结构相似性。在人体许多组织内，具有广泛的生物学活性，参与一系列重要的生理和病理过程，具有临床治疗的潜在效果。本书共分九章，从FGF总论、FGF与受体及其结构与功能、FGF与疾病和FGF与生物工程等角度，系统整理了国内外有关FGF的最新研究成果，阐述了FGF基础研究和应用方面的进展和成果。

李校堃，微生物与生物技术药学专家，中国工程院院士，教授、博士生导师，温州医科大学党委副书记、校长、药学学科带头人，基因工程药物国家工程研究中心首席专家。于1992 年毕业于白求恩医科大学，1996年获中山医科大学医学博士学位。 2005 年入选教育部新世纪优秀人才，2008 年受聘为教育部“长江学者奖励计划”特聘教授， 2014 年入选“万人计划”第一批教学名师。长期致力于以成纤维细胞生长因子为代表的基因工程蛋白药物的基础研究、工程技术和新药研发、临床应用及转化医学研究，在国际上首次将成纤维细胞生长因子开发为临床药物。先后获得国家技术发明奖二等奖、国家科技进步奖二等奖等，发表论文200余篇。

The FGF Metabolic Axis
Chapter 1 Growth Factors Reviews
Fibroblast growth factors， old kids on the new block
Pharmacological application of growth factors： basic and clinical
Cytokines and diabetes research
Small molecule inhibition of fibroblast growth factor receptors in cancer
Research advances in tissue engineering materials for sustained release of growth factors
Minireview： roles of fibroblast growth factors 19 and 21 in metabolic regulation and chronic diseases
Physiological and pharmacological roles of FGF21 in cardiovascular diseases
Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
Delivery of growth factor-based therapeutics in vascular diseases： challenges and strategies
Fibroblast growth factor 10 in pancreas development and pancreatic cancer
Chapter 2 Injury Repair and Regeneration
TAT-mediated acidic fibroblast growth factor delivery to the dermis improves wound healing of deep skin tissue in rat
Regulation of autophagy and ubiquitinated protein accumulation by bFGF promotes functional recovery and neural protectzion in a
rat model of spinal cord injury
The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo
Exogenous basic fibroblast growth factor inhibits ER Stress-induced apoptosis and improves recovery from spinal cord injury
FGF10 protects against renalischemia/reperfusion injury by regulating autophagy and infiammatory signaling
Reduction of cellular stress is essential for Fibroblast growth factor 1 treatment for diabetic nephropathy
Chapter 3 Endocrinology and Metabolism
Fibroblast growth factor 21 （FGF21） therapy attenuates left ventricular dysfunction and metabolic disturbance by improving
FGF21 sensitivity， cardiac mitochondrial redox homoeostasis and structural changes in pre-diabeticrats
NMR-based metabolomics reveal a recovery from metabolic changes in the striatum of 6-OHDA-induced rats treated with basic
fibroblast growth factor
FGF21 mediates alcohol-induced adipose tissuelipolysis by activation of systemic release of catecholamine inmice
Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice
Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and
induction of adiponectininmice
Attenuation of hyperlipidemia and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration
offibroblast growth factor-21 is associated with suppression of renal infiammation
The prevention of diabetic cardiomyopathy by non-mitogenic acidic fibroblast growth factor is probably mediated by the
suppression of oxidative stress and damage
Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a
PI3K/Akt signaling-dependent manner
……
Chapter 4 Structure and Modification
Chapter 5 Signaling Pathway and Pharmacology
Chapter 6 Pharmaceutics and New Material
Chapter 7 Bioreactor and Engineering
Chapter 8 FGFR and Inhibitors
Chapter 9 Others