间质性膀胱炎是一种以严重尿急、尿频、夜尿次数增加，耻骨上疼痛，膀胱充盈疼痛加重，排尿后疼痛减轻，尿常规检查和细菌培养阴性为特征的一组综合症，对患者的精神心理和生活质量的影响不亚于癌症，国内外还没有一部系统介绍其基础与临床诊疗研究的专著。全书共设30章，重点介绍间质性膀胱炎的认识、命名与演变史，流行病学与症状患病率，膀胱壁组织结构与生理功能；病因机制，神经生物学与疼痛；诊断与鉴别诊断方法，尿液相关分子标记物，尿流动力学与鉴别诊断，超声表现与评价，成像技术与表现特点，诊疗指南，患者初始管理与辅助治疗，微能量物理治疗原理与实践，中医学辨证论治、方药选择，灌注药物与疗效评价，肉毒杆菌毒素治疗与评价，膀胱水囊扩张术应用，外科治疗方法与适应症，患者健康教育与护理等。为了知识的系统性，本书还增加了动物实验模型的建立与评价，临床数据库的设计与网络信息资源查询与应用等相关内容。

间质性膀胱炎是一种以严重尿急、尿频、夜尿次数增加，耻骨上疼痛，膀胱充盈疼痛加重，排尿后疼痛减轻，尿常规检查和细菌培养阴性为特征的一组综合症，对患者的精神心理和生活质量的影响不亚于癌症，国内外还没有一部系统介绍其基础与临床诊疗研究的专著。全书共设30章，重点介绍间质性膀胱炎的认识、命名与演变史，流行病学与症状患病率，膀胱壁组织结构与生理功能；病因机制，神经生物学与疼痛；诊断与鉴别诊断方法，尿液相关分子标记物，尿流动力学与鉴别诊断，超声表现与评价，成像技术与表现特点，诊疗指南，患者初始管理与辅助治疗，微能量物理治疗原理与实践，中医学辨证论治、方药选择，灌注药物与疗效评价，肉毒杆菌毒素治疗与评价，膀胱水囊扩张术应用，外科治疗方法与适应症，患者健康教育与护理等。为了知识的系统性，本书还增加了动物实验模型的建立与评价，临床数据库的设计与网络信息资源查询与应用等相关内容。

"第一章  间质性膀胱炎认识与演变史 ···················································································1
第一节  间质性膀胱炎的认识起源 ················································································1
第二节  间质性膀胱炎的命名与演变 ·············································································3
第三节  间质性膀胱炎国际协作组织的起源与发展 ···························································7
第二章  间质性膀胱炎流行病学与症状患病率 ·····································································11
第一节  流行病学与相关研究 ····················································································11
第二节  间质性膀胱炎症状患病率 ··············································································13
第三节  工作效率与医疗保险利用率 ···········································································17
第三章  膀胱壁组织结构与相关生理学功能 ········································································19
第一节  膀胱黏膜上皮的结构与功能特点 ·····································································19
第二节  膀胱黏膜上皮的生理与生物学功能 ··································································21
第三节  膀胱平滑肌的结构与细胞生理功能 ··································································33
第四节  调控膀胱排尿功能的神经系统 ········································································38
第五节  调控膀胱排尿功能的化学信号、受体与传导通路 ················································44
第六节  间质性膀胱炎病理生理与膀胱功能的改变 ·························································56
第四章  肥大细胞与间质性膀胱炎 ····················································································78
第一节  概述 ·········································································································78
第二节  肥大细胞的起源与迁移 ·················································································79
第三节  肥大细胞的表型与分布 ·················································································81
第四节  肥大细胞的发育与成熟 ·················································································82
第五节  肥大细胞的激活与脱颗粒 ··············································································83
第六节  肥大细胞与间质性膀胱炎的相关证据 ·······························································87
第五章  膀胱黏膜上皮损伤与间质性膀胱炎 ········································································91
第一节  概述 ·········································································································91
第二节  黏膜组织结构与细胞生物学功能 ·····································································92
第三节  间质性膀胱炎黏膜损伤与病理组织学证据 ·························································95
第四节  结语 ·········································································································99
第六章  雌激素与间质性膀胱炎 ······················································································102
第一节  概述 ········································································································102
第二节  雌激素-受体与膀胱上皮细胞 ·······································································105
第三节  雌激素与肥大细胞雌激素受体 ·······································································106
第四节  雌激素水平变化与间质性膀胱炎症状的相关性 ··················································107
第五节  雌激素阻断剂治疗间质性膀胱炎作用与评价 ·····················································108
第六节  结语 ········································································································109
第七章  获得性免疫与间质性膀胱炎 ················································································112
第一节  获得性免疫的概念 ······················································································112
第二节  获得性免疫的构成与功能 ·············································································113
第三节  获得性免疫反应与间质性膀胱炎 ····································································119
第四节  间质性膀胱炎膀胱挛缩的病因机制 ·································································121
第八章  神经生物学与间质性膀胱炎疼痛机制 ····································································126
第一节  概述 ········································································································126
第二节  神经源性炎症与膀胱疼痛 ·············································································129
第三节  间质性膀胱炎膀胱疼痛与周围神经敏化 ···························································131
第四节  间质性膀胱炎膀胱疼痛与中枢神经敏化 ···························································132
第九章  间质性膀胱炎诊断与鉴别诊断方法 ·······································································135
第一节  概述 ········································································································135
第二节  临床表现与症状特点 ···················································································136
第三节  IC症状评分系统与评价 ················································································137
第四节  实验室检查与尿液分析 ················································································143
第十章  间质性膀胱炎与尿液相关分子标志物 ····································································147
第一节  概述 ········································································································147
第二节  间质性膀胱炎与白细胞介素 ··········································································149
第三节  趋化因子表达与间质性膀胱炎 ·······································································152
第四节  血管内皮生长因子表达与间质性膀胱炎 ···························································153
第五节  肿瘤坏死因子与间质性膀胱炎 ·······································································156
第六节  神经生长因子与间质性膀胱炎疼痛机制 ···························································158
第七节  类胰蛋白酶与间质性膀胱炎 ··········································································163
第八节  糖胺聚糖与间质性膀胱炎 ·············································································166
第九节  问题与展望 ·······························································································168
第十一章  间质性膀胱炎尿流动力学表现与鉴别疾病 ···························································170
第一节  概述 ········································································································170
第二节  尿流动力学原理与方法 ················································································171
第三节  间质性膀胱炎尿流动力学表现 ·······································································179
第四节  尿流动力学用于间质性膀胱炎的鉴别诊断 ························································181
第五节  结语 ········································································································182
第十二章  超声在间质性膀胱炎诊断中的应用 ····································································184
第一节  概述 ········································································································184
第二节  正常膀胱壁的超声表现 ················································································185
第三节  间质性膀胱炎的超声表现 ·············································································187
第四节  超声对间质性膀胱炎相关疾病的鉴别诊断 ························································188
第五节  问题与展望 ·······························································································191
第十三章  成像技术与间质性膀胱炎 ················································································193
第一节  概述 ········································································································193
第二节  成像技术基本原理与应用 ·············································································194
第三节  磁共振成像技术原理与进展 ··········································································195
第四节  正常膀胱壁磁共振成像与结构特点 ·································································197
第五节  间质性膀胱炎磁共振成像与结构改变 ······························································198
第六节  磁共振功能成像对间质性膀胱炎疼痛的中枢定位研究 ·········································200
第十四章  间质性膀胱炎诊断指南与评价 ··········································································203
第一节  欧洲泌尿外科学会间质性膀胱炎诊断指南与评价 ···············································203
第二节  美国泌尿外科学会间质性膀胱炎诊断指南与评价 ···············································205
第三节  加拿大泌尿外科学会间质性膀胱炎诊断指南与评价 ············································207
第十五章  男性间质性膀胱炎的认识与诊疗原则 ·································································214
第一节  概述 ········································································································214
第二节  流行病学与发病率 ······················································································214
第三节  病因与病理 ·······························································································215
第四节  诊断与鉴别诊断 ·························································································216
第五节  间质性膀胱炎治疗原则与方法 ·······································································219
第六节  问题与展望 ·······························································································219
第十六章  间质性膀胱炎患者初始管理与辅助治疗 ······························································221
第一节  概述 ········································································································221
第二节  患者教育 ··································································································221
第三节  社会心理支持 ····························································································222
第四节  共存疾病的治疗 ·························································································223
第五节  饮食控制与评价 ·························································································223
第六节  行为治疗与评价 ·························································································224
第七节  认知行为疗法 ····························································································225
第八节  意象导引 ··································································································226
第九节  哈他瑜伽 ··································································································227
第十节  膈式呼吸 ··································································································227
第十一节  矛盾松弛 ·······························································································228
第十二节  针刺疗法 ·······························································································228
第十三节  结语 ·····································································································229
第十七章  微能量物理治疗间质性膀胱炎的应用研究 ···························································231
第一节  概述 ········································································································231
第二节  微能量治疗间质性膀胱炎的基本原理和机制 ·····················································234
第三节  微能量技术治疗间质性膀胱炎的方法及效果评价 ···············································240
第四节  问题与展望 ·······························································································242
第十八章  指南推荐的间质性膀胱炎治疗药物与药效作用 ·····················································244
第一节  概述 ········································································································244
第二节  指南推荐的行为与非药物治疗原则 ·································································245
第三节  指南推荐的口服治疗药物 ·············································································247
第四节  非指南推荐的治疗药物 ················································································251
第五节  问题与展望 ·······························································································252
第十九章  中医对间质性膀胱炎的认识与辨证论治 ······························································254
第一节  中医学对间质性膀胱炎的认识 ·······································································254
第二节  中医分型与治则治法 ···················································································255
第三节  中药方剂组成与药效作用 ·············································································256
第四节  中西药结合治疗方案与评价 ··········································································258
第二十章  中医络病学对间质性膀胱炎病因病机的认识与方药选择 ·········································261
第一节  概述 ········································································································261
第二节  中医络病学与间质性膀胱炎的关系 ·································································262
第三节  中医络病学与膀胱的解剖相关 ·······································································262
第四节  中医络病学与间质性膀胱炎的生理相关 ···························································262
第五节  中医络病学与间质性膀胱炎的病理相关 ···························································263
第六节  从中医络病辨证分析间质性膀胱炎的病因 ························································264
第七节  基于中医络病学探讨间质性膀胱炎治法与方药 ··················································265
第八节  基于中医络病学探索间质性膀胱炎的诊疗思路 ··················································267
第二十一章  中医学对女性性功能障碍的认识 ····································································270
第一节  概述 ········································································································270
第二节  女性性功能的中医调节机制 ··········································································271
第三节  中医对女性间质性膀胱炎性功能障碍的认识 ·····················································273
第四节  女性间质性膀胱炎性功能障碍的症候分型 ························································276
第五节  中医辨证论治与方药选择 ·············································································276
第二十二章  间质性膀胱炎灌注药物与疗效评价 ·································································285
第一节  膀胱内常用灌注药物与原理 ··········································································285
第二节  药物灌注治疗与相关护理 ·············································································287
第三节  药物灌注疗程与疗效的评估方法 ····································································288
第四节  问题与展望 ·······························································································289
第二十三章  膀胱壁肉毒杆菌毒素治疗疗效与评价 ······························································291
第一节  概述 ········································································································291
第二节  肉毒杆菌毒素A逼尿肌注射治疗作用机制 ························································291
第三节  肉毒杆菌毒素A逼尿肌注射治疗方法与选择 ·····················································294
第四节  肉毒杆菌毒素A逼尿肌注射临床疗效与评价 ·····················································295
第五节  问题与展望 ·······························································································295
第二十四章  间质性膀胱炎膀胱水囊扩张术的应用与评价 ·····················································298
第一节  概述 ········································································································298
第二节  膀胱水囊扩张术应用与评价 ··········································································298
第三节  术后并发症与随访治疗 ················································································300
第四节  临床疗效与评价要点 ···················································································303
第二十五章  间质性膀胱炎外科治疗方法与评价 ·································································306
第一节  骶神经调控术治疗间质性膀胱炎 ····································································306
第二节  Hunner溃疡与红斑TUR切除术 ······································································315
第三节  间质性膀胱炎原位膀胱扩大术 ·······································································317
第四节  膀胱切除与输尿管造口术 ·············································································321
第五节  腹腔镜膀胱切除与回肠原位新膀胱术 ······························································328
第二十六章  间质性膀胱炎患者预防调护与健康教育 ···························································339
第一节  概述 ········································································································339
第二节  患者的健康教育 ·························································································339
第三节  精神心理支持与护理 ···················································································340
第四节  饮食调控与指导 ·························································································340
第五节  行为治疗与疼痛护理 ···················································································340
第六节  性功能障碍与预防调护 ················································································341
第七节  外科治疗与术后护理 ···················································································342
第二十七章  间质性膀胱炎与相关综合征 ··········································································345
第一节  前列腺疼痛综合征 ······················································································345
第二节  膀胱过度活动症 ·························································································353
第三节  子宫内膜异位症 ·························································································367
第四节  纤维肌痛综合征 ·························································································372
第五节  阴囊疼痛综合征 ·························································································377
第六节  睾丸疼痛综合征 ·························································································382
第七节  附睾疼痛综合征 ·························································································386
第八节  阴茎疼痛综合征 ·························································································390
第九节  尿道疼痛综合征 ·························································································394
第十节  输精管切除术后阴囊疼痛综合征 ····································································396
第十一节  阴部神经卡压综合征 ················································································402
第十二节  功能性肛门直肠痛 ···················································································407
第十三节  肠易激综合征 ·························································································413
第十四节  慢性疲劳综合征 ······················································································417
第二十八章  间质性膀胱炎动物模型的建立与评价 ······························································433
第一节  鱼精蛋白法建立小鼠膀胱上皮GAG损伤模型与评价 ···········································433
第二节  脂多糖灌注法建立小鼠间质性膀胱炎模型与评价 ···············································437
第三节  鱼精蛋白/脂多糖联合灌注用于鼠间质性膀胱炎模型的建立与评价 ························440
第四节  环磷酰胺腹腔注射法建立鼠间质性膀胱炎模型的应用与评价 ································442
第五节  转基因小鼠间质性膀胱炎模型的建立与评价 ·····················································445
第二十九章  间质性膀胱炎临床数据库的设计与应用 ···························································451
第一节  概述 ········································································································451
第二节  数据库系统的概念 ······················································································452
第三节  数据库设计技术 ·························································································452
第四节  间质性膀胱炎系统相关数据库的设计 ······························································454
第五节  间质性膀胱炎数据库系统应用方法 ·································································465
第六节  结语 ········································································································474
第三十章  间质性膀胱炎网络资源查询与应用 ····································································477
第一节  概述 ········································································································477
第二节  医学网络搜索引擎 ······················································································478
第三节  医学文献英文数据库 ···················································································481
第四节  中文文献数据库 ·························································································484
第五节  间质性膀胱炎常用相关网址 ··········································································485
英汉关键词对照 ···········································································································496"