本书从基本方法和原理出发，论述了高分子微结构修饰调控材料表界面性能的先进技术与设计。主要内容包括高分子微结构修饰方法如自组装单分子层法、微区接触反应法、平板印刷法等，及其在生物学领域中的巨大应用前景如诱导细胞定向生长、生物分子检测、肿瘤细胞灵敏抓捕等。本书可供高分子材料领域研究人员，以及从事材料表界面设计的料研工作者和相关研究生参考。

Chapter 1 Reactive Platforms for Controllable Fabrication of Functional
(Bio)Interfaces
1.1 Scope of Surface Modification for (Bio)Reactive Platfor ms
and Functional (Bio)Interfaces
1.2 Chemical and Topographical Pattern Fabrication
from Micrometer to Nanometer Length Scales
References
Chapter 2 Surface Reactions and Fabrication of Bioreactive Platforms
Based on Organic and Polymeric Films: From Micrometer
to Nanometer Length Scale
2.1 Introduction: Bioreactive Platforms and Biointerfaces
via Organic and Polymeric Films
2.1.1 Organic and Polymeric Films
2.1.2 Pattern Fabrication on Organic and Polymeric Films
2.2 Surface Reactions of Organic and Polymeric Films
2.2.1 Self-assembled Monolayers
2.2.2 Surface Modification with Polymers
2.3 Patterned Organic and Polymeric Films for Tailored
(Bio)Interfaces
2.3.1 Microcontact Printing
2.3.2 Selective Molecular Assembly Patterning (SMAP)
2.3.3 Embossing and Nano-Imprinting
2.3.4 Self-assembled Block Copoly mer Patterns
References
Chapter 3 Confinement Effects on the Reactivity in Ultrathin Polymer
Films: Kinetics and Temperature Dependence of the Hydrolysis
of NHS and TBA Esters
3.1 Introduction
3.2 Ultrathin PNHSMA Polymer Films
3.2.1 Characterization of the Hydrolysis of PNHSMA Films
3.2.2 Temperature Dependence of Reaction Kinetics
3.2.3 Comparison of Surface Reactions in SAMs
and Ultrathin Polymer Films
3.3 Ultrathin PS_-b-PiBA_ Polvmer Films
3.3.1 Characterization of Polymer Thin Film Surface
Composition
3.3.2 Characterization and Kinetics of the Hydrolysis
of PSm-b-PtBA, Films
3.3.3 Investigation of the Temperature Dependence
of Reaction Kinetics
3.3.4 Effects of Film Thickness and Thermal Pretreatment
on Reaction Rates
3.3.5 Dependence of Hydrolysis Kinetics on Surface
Composition
3.3.6 Comparison of Reactivity of T-Butyl Esters
in PS,-b-PtBAm Thin Films and in Solution
3.4 Experimental Section
References
Chapter 4 Reactive Thin Polymer Films as Platfor ms
for the Immobilization of Biomolecules
4.1 Introduction
4.2 Investigation of the Reactivity of PNHS MA
4.2.1 Coupling of PEGsoo-NH2
4.2.2 Coupling of Fluoresceinamine and BSA to PNHSMA
Films1wvve
4.2.3 Comparison of Surface Reactions on PNHSMA Films
and NHS-C10 Monolayers
4.3 Swelling Behavior and Stability of PNHSMA Films
4.4 Immobilization of DNA and Surface-Based Hybridization
4.4.1 DNA Immobilization Studied by SPR
4.4.2 Investigation of DNA Hybridization by SPFS
and Fluorescence Microscopy
4.5 Toward the Detection of Pathogenic Bacteria on PNHSMA
Films
4.6 Experimental Section
References
Chapter 5 Tailored Biointerfaces via Derivatization
of Polystyrene-b-Poly(Tert-Butyl Acrylate) Thin Films
5.1 Introduction
5.2 Investigation of the Surface Chemistry of PS690-b-PtBA1210
Films
5.2.1 Surface Hydrolysis of PS690-b-PtBA1210 Films
5.2.2 Covalent Coupling of PEG to Activated
PSkon-b-PtBA n Films
5.3 Covalent Coupling of Biomolecules to Activated
PS690-b-PtBA1210 Films
5.4 Cell Adhesion Studies on PSs90-b-PtBA1210 Films
5.5 Experimental Section
References
Chapter 6 Fabrication of Robust Biomolecular Patterns by Reactive
Microcontact Printing on NHS Ester Containing Polymer Films
6.1 Introduction
6.2 Approaches for Micropatterning of PNHSMA Films
6.3 Functionalization of PNHSMA Films by Reactive u.CP
6.4 Non-specific Adsorption (NSA)
6.5 Patterning of PNHSMA and Coupling of (Bio)Molecules
to Patterned Films
6.6 DNA Hybridization
6.7 Experimental Section
References
Chapter 7 Reactive uCP on Ultrathin Block Copolymer Films
Investigation of the uCP Mechanism and Applications
to Sub-um (Bio)Molecular Patterning
7.1 Introduction
7.2 Strategy A: Fabrication of Multimo