Jie Tian Editor《Molecular Imaging》 Fundamentals and Applications is a comprehen-sive monograph which describes not only the theory of the under-lying algorithms and key technologies but also introduces a prototype system and its applications，bringing together theory,technology and applications．

Jie Tian Editor《Molecular Imaging》 Fundamentals and Applications is a comprehen-sive monograph which describes not only the theory of the under-lying algorithms and key technologies but also introduces a prototype system and its applications，bringing together theory,technology and applications．

By explaining the basic concepts and principles of molecular imaging，imaging techniques，as well as research and applications in detail，《Molecular Imaging》 provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences．Clinical doctors and graduate students will also benefit from this book．

Part I Molecular Imaging Theory and System

1 Introduction

1．1 Development ofMolecular Imaging

1．2 Advantages ofMolecular Imaging

1．3 Basic Pfinciples ofMolecular Imaging Modalities

1．4 Generous Development ofMolecular Imaging Probe

1．5 Application Involving Molecular Imaging

References

2 Molecular Optical Simulation Environment

2．1 Introduction

2．2 Review ofthe Current Simulation PlatforlTl

2．3 Introduction 0fMOSE

2．4 Introduction ofthe Algorithm

2．5 Validation ofthe Simulation Experiment Results．

References

3 Diffuse Optical Tomography

3．1 Outline

3．2 Medical Background and Optical Properties of Human Tissue

3．3 Photon Transport Model in Tissues and Image Reconstruction

Algorithms

 3．4 Simulative and Experimental Tomographic and Topographic

Imaging on a Phantom

References

4 Fluorescence Molecular Tomography

4．1 Overview

4．2 Fundamental Principles in Fluorescence Molecular Tomography

4．3 Experimental System in Fluorescence Molecular Tomography．

4．4 The Reconstruction Algorithms in Fluorescence Molecular Tomography

4．5 Experiment in Fluorescence Molecular Tomography References

5 Bioluminescenee Tomography

5．I Introduction

5．2 The Forward Model for BLT

5．3 BLT Reconstruction Algorithms

5．4 Experiments and Applications

References

6 Positron Emission Tomography

6．1 Prologue

6．2 The Principle ofPET

6．3 Positron Emission Tomography Scanner

6．4 Reconstruction Algorithms and Correction Techniques in PET

6．5 PET／CT Image Fusion

6．6 Experimental PET Imaging References

7 Radioisotope Labeled Molecular Imaging in SPECT

7．1 Outline ofMolecular Imaging in SPECT

7．2 Key Technologies ofAnimal Pinhole SPECT References

8 MRI Facility-Based Molecular Imaging．

8．1 Outline ofthe MIU Facility—Based Molecular Imaging

8．2 Main mMgI Contrasts．

References．

9 Other Molecular Imaging Technology

9．1 Photoacoustic Tomography

9．2 Optical Coherence Tomography

9．3 Confocal Laser Scanning Microscopy．

9．4 Ultrasound in Molecular Imaging．

9．5 X—Ray Micro-Computed Tomography．

References．

10 Optical Multi-Modality Molecular Imaging

10．1 Fusion ofBLT and Nicro-CT System

10．2 Fusion ofDOT and BLT Systems

10．3 Multi—Mod~ity Imaging ofFMT and CT

10．4 Image Registration and Fusion Between SPECT and CT．

References

11 Medical Image Processing and Analysis

11．1 Overview．

11．2 Medical Image Segmentation

11．3 Medical Image Registration

11．4 New Techniques ofImage Fusion

11．5 Medical Image Visualization．

Reference

PartII Molecular Probes

12 Opportunities and Challenges of Radiolabeled Molecular Probes

12．1 Introduction

12．2 The Opportunities ofRadiolabeled Molecular Probes．

12．3 The Challenges ofRadiolabeled Molecular Probes

12．4 Summary．

References

13 oli20nucleotide Probes

13．1 Design Principle ofOligonucleotide Probes

13．2 Anti．Nuclease Modification ofOligonucleotide Probes

13．3 Delivery ofProbes into Cells

References

14 Quantum Dots for Biological Imaging

14．1 ODs Based on CdTe

14．2 ODs Based on CdSe

14．3 ODs Based on CdSe／ZnS

14．4 QDs Based on CdSe／CdS／ZnS

14．5 0Ds Based on InP／ZnS

14．6 QDs Based on CdHgTe

14．7 ODs Based on Lead Salts

14．8 Other QDs

References

15 RGD-Based Molecular Probes for Integr in αvβ3Imaging

15．1 Introduction

15．2 Multi—Modality RGD Probes Targeting Integrin αvβ3

15．3 Dual Functional RGD Probes for Integrin αvβ3 Targeting．

15．4 Optimizmion OfRGD Probes 

15．5 Conclusions and Future Perspectives

References

Part III Applications of Molecular Imaging．

16 Basics of Molecular Biology

16．1 Introduction．

16．2 Techniques ofMolecular Biology．

16．3 Cells and Viruses

16．4 Transcription

16．5 Transcription and Translation in Eukaryotes

16．6 Post．Transcriptional Events

16．7 DNA Replication and Recombination

16．8 DNA Damage and Repair

16．9 Transiation

References．

17 Molecular Imaging Techniques in Clinical Practice of Tumors

17．1 Application of Molecular Imaging Techniques in Tumor

Diagnosis and Differentiation

17．2 Application of Molecular Imaging Techniques in the Clinical

Staging ofMalignancies

17．3 Application ofMolecular Imaging Techniques in Lymph Nodes

Evaluation

17．4 Application of Molecular Imaging Techniques in Tumor

Therapeutic Monitoring and Efficacy Evaluation

17．5 Application ofMolecular Imaging Techniques in Other Aspects

ofCancer Therapy

17．6 Conclusions and Prospects．

References

18 Using Molecular Imaging Techniques to Study Protein-Protein

Interactions．

18．1 The Yeast Two—Hybrid System．

18．2 FRET

18．3 BRET

18．4 PCA

18．5 Concluding Remarks

References

19 Application of Molecular Imaging in Transgenic Animals

19．1 The Stem Cells

19．2 Molecular Imaging in Stem Cell Research for Heart Repair

19．3 Molecular Imaging in Stem Cell Research for Kidney Repair

19．4 Molecular Imaging in Stem Cell Research for Liver Repair

19．5 Molecular Imaging in Neural Stem Cell Research

19．6 Conclusion

References．

20 Molecular Imaging Methods in Diabetes-Related Studies

20．1 Molecular Imaging Applications in Diabetes—Related Fundamental

Research

20．2 Molecular Imaging Assists Diabetic—Related Therapeutic Research

20．3 Recent Advances in Molecular Imaging．

20．4 Concluding Remarks

References

Index