陈志南编著的《陈志南院士集(精)》介绍了，陈志南，中国工程院院士，肿瘤细胞生物学与生物技术药物专家、教授、博士生导师。现任第四军医大学细胞工程研究中心细胞生物学国家重点学科主任，国家分子医学转化科学中心主任，兼任中国工程院医药卫生学部常委、“重大新药创制”国家科技重大专项技术副总师、军队特需药品专项技术副总师、国家“863”计划生物与医药技术领域专家、国家药典委员会执行委员、国家“973”计划项目首席科学家、国家科学技术奖评审专家、中国转化医学与生物技术创新联盟理事长、中国细胞生物学学会副理事长兼细胞工程与转基因生物分会会长、中国药学会副理事长兼生化与生物技术药物专业委员会主任委员、中国抗癌协会常务理事兼肿瘤标志专业委员会主任委员、军队医学科学技术委员会基础与药学领域副主任委员兼转化医学专业委员会主任委员。

陈志南编著的《陈志南院士集(精)》是《中国医学院士文库》的分册之一。本书由三部分组成。第一部分奋斗历程，介绍了院士的主要经历和事业发展的宝贵经验；第二部分学术贡献，包括院士的主要学术论文、学术著作以及学术年表等，反映了院士在理论创新和技术进步的主要成果及其价值；第三部分人生风采，以丰富的图片资料展示了院士在不同时间工作、讲学、国际交流、社会活动和业余生活等方面的风采。全书充分诠释了陈志南院士的学术成就、学术思想和学术风范，可供广大医学工作者，特别是从事细胞生物学、肿瘤生物学、生物技术药物研究的科研人员、临床医务工作者学习、借鉴。

第一部分 奋斗历程

 陈志南院士简介

 锲科学之难题而不舍持学术之精神以永恒

 陈志南院士主要学术职务

第二部分 学术贡献

 一、陈志南院士的主要学术论文

Randomized Trial of [131I] Metuximab in Treatment of Hepatocellular CarcinomaAfter Percutaneous Radiofrequency

Ablation

HAb18G/CD147 Promotes Cell Motility by Regulating Annexin Ⅱ-Activated RhoAand Racl Signaling Pathways in

Hepatocellular Carcinoma Cells

A Randomized Controlled Trial of Licartin for Preventing Hepatoma RecurrenceAfter Liver Transplantation

HAb18G/CD147 Promotes Activation of Hepatic Stellate Cells and is a Target for Antibody Therapy of Liver Fibrosis

CD147 Induces UPR to Inhibit Apoptosis and Chemosensitivity

by Increasing the Transcription of Bip in Hepatocellular Carcinoma

HAblSG/CD147 Promotes Epithelial-Mesenchymal Transition through TGF-13 Signaling and is Transcriptionally

Regulated by Slug

Leukocyte Telomere Length Predicts Overall Survival in Hepatocellular Carcinoma Treated with Transarterial

Chemoembolization

Hypoxia Upregulates CD147 through a Combined Effect of HIF-la and Spl to Promote Glycolysis and Tumor Progression

in Epithelial Solid Tumors

GWAS-Identified Colorectal Cancer Susceptibility Locus Associates with Disease Prognosis

Characterization of Basigin Isoforms and the Inhibitory Function of

Basigin-3 in Human Hepatocellular Carcinoma Proliferation and Invasionv

Crystal Structure of HAb18G/CD147

Overexpression of HAb18G/CD147 Promotes Invasion and Metastasis via α3βl Integrin Mediated FAK-Paxillin and FAK-PI3K-Ca2+ Pathways

A Protein Chip Approach for High-Throughput Antigen Identification and Characterization

Extracellular Membrane-Proximal Domain of HAb18G/CD147 Binds to Metal

Ion-dependent Adhesion Site (MIDAS) Motif of Integrin β1 to Modulate Malignant Properties of Hepatoma Cells

Comprehensive Pathway-Based Interrogation of Genetic Variations in the

Nucleotide Excision DNA Repair Pathway and Risk of Bladder Cancer

Longer Leukocyte Telomere Length Predicts Increased Risk of Hepatitis

B Virus-Related Hepatocellular Carcinoma

Involvement of HAb18G/CD147 in T Cell Activation and Immunological Synapse Formation

RNA-Seq Analyses Generate Comprehensive Transcriptomic Landscape and Reveal Complex Transcript Patterns in Hepatocellular

Carcinoma

A Meta Analysis of Array-CGH Studies Implicates Antiviral Immunity Pathways in the Development of

Hepatocellular Carcinoma

HAb18G/CD147 Functions in Invasion and Metastasis of Hepatocellular Carcinoma

The Differential Expressions of 78-kDa Glucose-Regulated Protein of Infiltrating

Plasma Cells in Peripheral Joints with the Histopathological Variants of Rheumatoid Synovitis

Construction of RecombinantNewcastle Disease Virus Italien Strain for Oncolytic Virotherapy of Tumors

Promoter Hypomethylation Up-Regulates CD147 Expression through Increasing

Spl Binding and Associates with Poor Prognosis in Human Hepatocellular Carcinoma

Expression of CD147 on Monocytes/Macrophages in Rheumatoid Arthritis.

Its Potential Role in Monocyte Accumulation and Matrix Metalloproteinase Production

Genetic Polymorphisms in Pre-microRNA Genes as Prognostic Markers of Colorectal Cancer

HAblSG (CD147), a Cancer-associated Biomarker and Its Role in Cancer Detection

HAb18G/CD147 Inhibits Starvation-Induced Autophagy in Human Hepatoma Cell

SMMC7721 with an Involvement of Beclin 1 Down-Regulation

Annexin II Promotes Invasion and Migration of Human Hepatocellular Carcinoma Cells in vitro via its

Interaction with HAb18G/CD147

Transcription Factor Spl Regulates Expression of Cancer-Associated Molecule CD147 in Human Lung Cancer

Upregulation of HAb18G/CD147 in Activated Human Umbilical vein Endothelial Cells Enhances the Angiogenesis

Contribution of Cyclophilin A to the Regulation of Inflammatory Processes in Rheumatoid Arthritis

Optimal Design of Ig 5' Primers for Construction of Diverse Phage Antibody Library Established to Select

Anti-HAb18GEF and Anti-DOTA-Y Fabs for Hepatoma Pretargeting RIT

Targeting Radioimmunotherapy of Hepatocellular Carcinoma with Iodine (131I)

Metuximab Injection: Clinical Phase Ⅰ/ Ⅱ Trials

Radioimmunotherapy of Humancolon Cancer Xenografts by Using 131I Labeled-CAb F1 (ab')2

A Novel Antibody Fragment Targeting HAb18G/CD147 with Cytotoxicity and Decreased Immunogenicity

HAb18G/CD147 Cell-Cell Contacts Confer Resistance of a HEK293 Subpopulation to Anoikis in an E-Cadherin-Dependent Manner

Dimerization is Essential for HAb18G/CD147 Promoting Tumor Invasion via MAPK Pathway

Characterization of the Genome Sequence of an Oncolytic Newcastle Disease Virus Strain Italien

High Efficiency Reconstitution of a Human-Mouse Chimeric Fab of CAb-1 Antibody Specific to Human Colon Cancer

New Strategy for Large-scale Preparation of the Extracellular Domain of Tumor-Associated Antigen HAb18G/CD147 (HAb18GED)

抗人肝细胞癌单克隆抗体的产生及其相应抗原P60的免疫组化定位研究

 二、陈志南院士的主要学术著作

抗体分子与肿瘤

激光扫描共聚焦显微镜技术

重组抗体

细胞工程

工程细胞生物学

 三、陈志南院士学术年表

陈志南院士学术论文目录

陈志南院士主要著作目录

陈志南院士的专利授权目录

陈志南院士主要获奖目录

第三部分 人生风采

 科研教学

 学术交流

 珍贵留影