《中国医学院士文库》从文化出版与医疗卫生这两个行业的结合点上，准确地把握住了军地医务人员对弘扬医德医风、提升医疗技术的深层需求和期待，广大医务人员可以从中领略、学习到我国医学界名医大家不畏艰辛的奋斗历程、科学严谨的治学风范、勇于创新的学术精神、开阔深刻的思维品质。

《沈倍奋院士集》充分诠释了沈倍奋院士的学术成就、学术思想和学术风范，可供广大医学工作者，特别是从事免疫学科研、教学的专业人员学习、借鉴。

《沈倍奋院士集》是《中国医学院士文库》的分册之一。本书由五部分组成。第一部分奋斗历程，介绍了院士的主要经历和事业发展的宝贵经验；第二部分学术贡献，包括院士的主要学术论文、学术著作以及学术年表等，反映了院士在理论创新和技术进步方面的主要成果及其价值；第三部分大师风范，记载了院士在培养人才和团队建设上为人师表的生动事例；第四部分社会影响，汇集了社会各界对院士学术成果和先进事迹的评价和赞誉；第五部分人生风采，以丰富的图片资料展示了院士在不同时期工作、讲学、国际交流、社会活动和业余生活等方方面面的风采。全书充分诠释了沈倍奋院士的学术成就、学术思想和学术风范，可供广大医学工作者，特别是从事免疫学科研、教学的专业人员学习、借鉴。

第一部分 奋斗历程

 一、沈倍奋院士自述

 二、沈倍奋院士简介

第二部分 学术贡献

 一、沈倍奋院士的学术成就与学术思想

 二、沈倍奋院士的主要学术论文

（一）人类白细胞分化抗原、抗体及其应用

人外周血淋巴细胞表面SRBC受体的研究

I.SRBC受体的分离和性质

人外周血淋巴细胞表面SRBC受体的研究

Ⅱ.亲和层析法提纯受体及其性质的研究

免疫毒素抑制靶细胞蛋白质合成的动力学研究

抗人T细胞单克隆抗体与蓖麻毒素结合物的制备及其细胞毒性质

免疫毒素清除人骨髓中克隆化白血病细胞的研究

CD9、CDl0单克隆抗体免疫毒素对白血病细胞的清除率及对造血细胞的影响

抗人白细胞分化抗原单克隆抗体免疫毒素在自体骨髓移植中的应用

抗T免疫毒素用于异基因骨髓移植的实验研究及初步应用

氨甲蝶呤一人血清白蛋白一单抗79结合物的制备及其体外细胞毒作用

基因分析在急性白血病分型中应用的基础研究

（二）白细胞介素6和白细胞介素6受体的研究

可溶性白细胞介素6受体J3亚基拮抗IL一6信号的研究

可溶性gpl30和gpl30反义核酸对IL一6诱导的靶基因启动子活性的影响

多发性骨髓瘤和白血病细胞中白细胞介素一6激活的核因子活性比较

IL一6信号转导与转录激活子活性研究

hIL一6·hIL一6Ra·gpl30三元复合物的结构预测

人白介素6与其受体结合特定结构域的预测

人骨髓瘤细胞中两条IL一6信号转导途径的相互调控方式

Effects of STAT3 Antisense RNA on IL-6-induced Differentiation and Growth

Arrest of M1 Leukemia Cells

Proteomic Analysis of Interleukin 6-induced Differentiation in Mouse Myeloid

Leukemia Cells

The Design of Antagonist Peptide of hIL-6 Based on the Binding Epitope of

hIL-6 by Computer-aided Molecular Modeling

（三）抗体工程研究

用噬菌体随机肽库确定抗TNF单抗识别的表位

Humanization of an Anti-human TNF-a Antibody by Variable Region Resurfacing

with the Aid of Molecular Modeling

Identification of Binding Epitope of a Monoclonal Antibody （Z12） Against Human

TNF-a Using Computer Modeling and Deletion Mutant Technique

Rational Design of Potent Mimic Peptide Derived from Monoclonal Antibody:

Antibody Mimic Design

De Novo Design TNF-a Antagonistic Peptide Based on the Complex Structure

of TNF-a with its Neutralizing Monoclonal Antibody Z12

A Novel Human scFv Fragment Against TNF-a from de novo Design Method

A Novel Domain Antibody Rationally Designed Against TNF-a Using Variable

Region of Human Heavy Chain Antibody as Scaffolds to Display Antagonistic

Peptides

Structured to Reduce the Mitogenicity of Anti-CD3 Antibody Based on

 Computer-guided Molecular Design

Novel Anti-CD20 Antibody TGLA with Enhanced Antibody-dependent

 Cell-mediated Cytotoxicity Mediates Potent Anti-lymphoma Activity

Structural Basis of LaDR5, a Novel Agonistic Anti-death Receptor 5 （DRS）

 Monoclonal Antibody, to Inhibit DR5/TRAIL Complex Formation

An Efficient and Targeted Gene Integration System for High-level

 Antibody Expression

Design and Assembly of Anti-CD16 ScFv Antibody with Two Different

 Linker Peptides

Structure-based Affinity Maturation of a Chimeric Anti-ricin Antibody CAC13

Affinity Maturation of" AntiHER2 Monoclonal Antibody MILS Using an

 Epitope-specific Synthetic Phage Library by Computational Design

（四）免疫耐受、自身免疫、细胞信号转导

Lineage-dependent NF-xB Activation Contributes to the Resistance of Human

Macrophages to Apoptosis

Active Tolerance Induction and Prevention of Autoimmune Diabetes by Immunogene

Therapy Using Recombinant Adenoassociated Virus Expressing Glutamic Acid

Decarboxylase 65 Peptide GADs00-~8s

Novel Strategies for Inhibition of the p38 MAPK Pathway

Autoantibody Profiling of Chinese Patients with Autoimmune Hepatitis Using

Immunoproteomic Analysis

MEKK30verexpression Contributes to the Hyperresponsiveness of IL-12

Overproducing Cells and CD4+ T Conventional Cells in Nonobese

Diabetic Mice

Defective Anchoring of JNK1 in the Cytoplasm by MKK7 in Jurkat Cells is

Associated with Resistance to Fas-mediated Apoptosis

Receptor for Activated C Kinase 1 Promotes Hepatocellular Carcinoma Growth

by Enhancing Mitogen-Activated Protein Kinase Kinase 7 Activity

T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the

TLR Response

Complement CSa Regulates IL-17 by Affecting the Crosstalk between DC and

73T Cells in CLP-induced Sepsis

Identification of Conformational Core Epitope Lys68 in CSa Based on the 3-D

Modeling Complex C5a and Its Functional Antibody F20

Blockade of Complement Activation Product C5a Activity Using Specific Antibody

Attenuates Intestinal Damage in Trinitrobenzene Sulfonie Acid Indueed Model of Colitis

Regulation of IL-8 Production by Complement-activated Product, C5a, in vitro and in vivo during Sepsis

（五）其他

抗尿激酶单克隆抗体识别相应抗原决定簇的研究

单克隆抗体亲和柱纯化尿激酶的研究

重组人粒细胞巨噬细胞集落刺激因子的研究

cDNA Cloning and Function Analysis of Two Novel Erythront Differentiation Related Genes

Initial Function Analysis of a Novel Erythroid Differentiation Related Gene EDRF1

Microarray—based Differential Expression Monitoring of 79 Novel Genes in

Differentiated K562 Cells

J2 Prolongs the Corneal Allograft Survival Through Inhibition of the CD4+T

Cell一megliated Response in Vivo

3D Structure of Human FK506binding Protein 52：Implications for the Assembly

of the Ghlcocorticoid Receptor／Hsp90／immunophilin Heterocomplex

利用荧光极化技术在均相系统内建立基于Bcl-2／Bak（作用模式的高通量药物筛选体系）

A Novel BLyS Antagonist Peptide Designe（1 BasedI on the 3一D Complex Structure

of BCMA and BLyS

Proteoml’c Analysis of Ubiquitin—proteasome Effects：Insight into the Function of

Eukaryotic Initiation Factor 5A

Identify the Key Amino Acid of BAFF Binding with TACI

 三、沈倍奋院士的主要著作

细胞调控的探索

分子文库

重组抗体

生物恐怖防御

公众应对恐怖事件常识

 四、沈倍奋院士学术年表

沈倍奋院士中文论文目录

沈倍奋院士英文论文目录

沈倍奋院士著作目录

沈倍奋院士科研成果目录

沈倍奋院士发明专利目录

第三部分 大师风范

前行的灯塔人生的导师

师恩难忘

踏实做事真实做人

学无止境天道酬勤

第四部分 社会影响

柔弱的执着——记中国工程院女院士、国家“863”计划生物技术领域专家委员会

委员沈倍奋

沈倍奋：“这件事我们得赶紧做”

她用生物导弹向白血病进攻——访军事医学科学院副研究员沈倍奋

科学品质和质朴人生——专访中国工程院院士沈倍奋

三分命运七分拼搏——记新世纪巾帼发明家、著名免疫学家沈倍奋

第五部分 人生风采

成长历程

学术活动

桃李满园

实至名归

幸福生活

院士近照