“以器官系统为中心”的医学教学模式是国际医学教育的趋势。本系列书是世界著名医药卫生出版集团爱思唯尔公司出版的一套“以器官系统为中心”的医学基础课程教材。该套教材第1版出版后受到世界各地许多医学院校的欢迎，并被多家进行“以器官系统为中心”教学的医学院校选定为教材。第2版根据第1版出版后教师和学生的反馈意见，结合医学知识的更新进行了全新修订。在编写内容上，该系列教材强调基础与临床的整合。每一章节都是围绕着一个临床病例展开，通过对病人问题的呈现以及解决过程引出对相关知识的探究，从而使与器官系统结构、功能以及疾病相关的重要的基础医学知识得到了完善的整合。在版式安排上，图框中的病例资料与正文中的医学知识完美匹配，一步一步地激起读者的求知欲望。本册为《心血管系统》。

1 A DESIGN SPECIFICATION FOR THE CARDIOVASCULAR SYSTEM

 Oxygen consumption

 Carriage of oxygen in blood

 Cyanosis

 The battle against the hydrogen ion: acid-base

 balance

 Cell injury and cell death

 Overall functional structure of the cardiovascular

 system

 Circulation time

 Structure and function of blood vessels

 Angiogenesis

 From cradle to grave--the presentation of heart

 disease.

2 CARDIAC MUSCLE STRUCTURE AND FUNCTION

 Cardiac muscle

 Structure of cardiac muscle

 Contractile mechanism in cardiac muscle

 Cardiac electrical activity

 Drugs which act on the heart

3 THE HEART AS A PUMP: VALVE FUNCTION AND VALVE DISEASE

 Functional anatomy of the heart

 The cardiac cycle

 Valve pathology

 History taking for cardiac disease

 Clinical examination of the cardiovascular system

 Investigations of heart disease: imaging the heart

 Sudden cardiac death

4 REGULATION OF CARDIAC FUNCTION

 Introduction

 Venous return

 Control of cardiac output

 Regulation of heart rate

 Regulation of stroke volume

 Preload effects on the heart

 Contractility effects on the heart

 Afterload effects on the heart

 Summary

5 BLOOD SUPPLY TO THE HEART

 Anatomy of the arterial supply and venous drainage

 of the heart

 Regulation of coronary blood flow

 Ischaemic heart disease

 Thrombosis

 Angina

 Myocardial infarction

 Coronary angioplasty and stenting

 Coronary artery bypass grafting

6 HEART FAILURE

 Systolic vs diastolic failure

 Haemodynamic events

 Metabolic events in heart failure

 Neurohormonal aspects of heart failure

 Drug therapy for heart failure

7 THE ELECTROCARDIOGRAM (ECG)

 Introduction

 Producing a -lead ECG

 The components of the ECG trace

 Practical use of the ECG

 The ECG and rhythm disturbances

 Cardiac structure and the ECG

 Ischaemia and the ECG

 Potassium and the ECG

 Drugs and the ECG

8 LARGE BLOOD VESSELS

 Introduction

 Haemorheology: the physical characteristics

 of blood flow

 Pathology of arteries and veins

 Atherosclerosis

 Vasculitis

 Varicose veins

 Vascular pathology of diabetes mellitus

 Aneurysms

 Non-invasive techniques for the assessment of

 arteries and veins

9 RESISTANCE BLOOD VESSELS

 Introduction

 Resistance to blood flow

 Vascular smooth muscle

 Local control of vascular smooth muscle

 Hormonal control of blood vessel diameter

 Autonomic nervous system and peripheral circulation

 control

 Special circulations

10 ARTERIAL BLOOD PRESSURE

 Introduction

 Arterial baroreceptors

 Cardiopulmonary reflexes

 Chemoreceptor reflexes

 Measurement of arterial blood pressure

 Pathological consequences of.raised arterial

 pressure

 Treatment of hypertension

 Hydrostatic pressure in the circulation

11 CAPILLARY FUNCTION AND THE LYMPHATIC SYSTEM

 Structure of capillaries

 Movement of substances across capillary walls

 Water movement across capillary walls

 The lymphatic system

 Oedema

12 FETAL CARDIOVASCULAR SYSTEM AND CONGENITAL HEART DISEASE

 Intoduction

 How does the transition from fetal to adult circulation

 occur?

 The normal ECG in childhood

 Congenital heart disease

 Early and late management of congenital heart

 disease

13 EXERCISE AND THE CARDIOVASCULAR SYSTEM

 Physiological responses to exercise

 Dynamic (isotonic) exercise

 Oxygen debt and the recovery from exercise

 Cardiovascular responses to static exercise

 Training effects of exercise

 Cardiovascular health benefits of exercise

 Clinical uses of exercise testing

14 HAEMORRHAGE AND CIRCULATORY SHOCK

 Introduction

 Arterial blood pressure changes in response to

 haemorrhage

 Short-term responses which help to restore lost blood

 volume

 Longer term responses which help to restore lost

 blood volume and electrolytes

 Decompensated or irreversible shock following

 haemorrhage

 Causes of shock

 Fluid replacement therapy

Glossary

Index