Experimental Pathological Pain: From Molecules to Brain Functions is the first academic monograph of English version introducing advancing knowledge about pain mechanisms and its control published by the Chinese publishers. The book is composed of 3 parts (22 chapters): (1) Neurobiology of pathological pain; (2) Neuromodulation of pathological pain and motor dysfunctions; (3) Neuroimaging of experimental human pain. It mainly concentrates on the underlying mechanisms and control strategies of experimental pathological pain with the contents ranging from molecular basis to brain functions and from animals to human beings.

The book will be useful to scientific researchers, clinicians, graduate and undergraduate students in the fields of biology, basic medicine and clinical medicine to get good understanding about advances in the study of pain and its management.

List of Contributing Authors

Foreword Ⅰ

Foreword Ⅱ

Preface

Acknowledgments

Part Ⅰ Neurobiology of Pathological Pain

1.Genetic Basis of Pain Induction and Modulation

2.Gene Expression in Naturopathic Pain Models

3.Peripheral Mechanisms and Modulation in Inflammatory Pain

4.A Contribution of Dorsal Root Reflexes to Neutrogenic Inflammation and Pain

5.Signal Molecules and Receptors in Primary Afferent Components of Nociceptive Processing and Plastic Changes

6.The Bee Venom Test：A Novel Useful Animal Model for Study of Spinal Coding and Processing of Pathological Pain Information

7.Trigeminal Mechanisms of Orofacial Pain

8.Application of Abult Rat Spinal Slice Patch-clamp Recording Technique in the Study of Nociceptive Transmission and Modulation

9.Temporal Firing Patterns and Responsiveness of Injured Sensory Neurons

10.Temporal Decoding of Persistent Pain Signal Processing in the Spinal Dorsal Horn：Application of Non-linear Dynamic Analytical Methods

11.Thalamo-Cortical System of Nociception in Animals

Part Ⅱ Neuromodulation of Pathological Pain and Motor Dysfunctions

12.Physiopharmacological Aspects of Pathological Pain States

13.Novel Pharmacology for Control of Chronic Pain

14.The Roles of 5-HT1A Receptor in Modulating Spinal Nociceptive Transmission in Inflammatory Rats

15.Low- and High-Frequency Electroacupuncture：Difference in Neural Pathways and Therapeutic Effects

16.Restitution of Upper-Limb Movement Promoted with Functional Electrical Therapy(FET)

17.Intranasal Morphine for Pain Manangement

Part Ⅲ Neuroimaging of Experimental Human Pain

18.Experimental Human Pain

19.EEG/MEC Brain Mapping of Human Pain

20.Principles of Human Pain Imaging with PET

21.The Application of Source Modelling to Functional Imaging of the Brain Based on EEG and MEG

22.Near-infrared Optical Imaging of the Human Brain