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书名 | 药物分析中的分离技术(英文版) |
分类 | 科学技术-医学-药学 |
作者 | |
出版社 | 南开大学出版社 |
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简介 | 内容推荐 《药物分析中的分离技术》是南开大学化学院为研究生和本科生开设的全英文课程,本教材为中英文双语教材。该教材旨在使学生掌握药物分析中各种分离技术的原理及其在药物分析中的应用;提高学生英语的听、说、读、写及交流能力;巩固仪器分析的知识,扩展学生的知识面,培养学生对科学研究的兴趣。每个章节后配有习题,教材后附有答案。教材中图文并茂,采用现代多媒体科技,通过引入二维码链接网络资源,读者用手机扫描二维码后可在线观看部分分析技术的原理,增加教材的生动、形象性和可读性。 目录 CHAPTER 1 INTRODUCTION TO THE PHARMACEUTIC ALANALYSIS 1.1 Nature and Tasks of Pharmaceutical Analysis 1.1.1 Pharmaceutical Analysis in the New Drug Discovery 1.1.2 Pharmaceutical Analysis to Ensure the Quality of Drug Product 1.1.3 Pharmaceutical Analysis in the Stability Studies 1.1.4 In Vivo Drug Analysis 1.2 National Standards for Supervision of Drug Quality 1.3 Significance of Separation Technology in the Pharmaceutical Analysis CHAPTER 2 CHROMATOGRAPHIC ANALYSIS 2.1 Theoretical Principle and Parameters 2.1.1 Theoretical Principles 2.1.2 Separation Parameters 2.1.3 Theoretical Plates of a Chromatographic Column 2.2 Gas Chromatography 2.2.1 Separation Mechanism 2.2.2 GC Instrument 2.2.3 GC Columns 2.2.4 Stationary Phases in GC 2.2.5 Stationary Phases in the GSC 2.2.6 Stationary Phases in the GLC 2.2.7 Detectors in GC 2.2.8 Advantages of GC 2.2.9 Applications of GC 2.3 Introduction to Liquid Chromatography 2.3.1 Columns in HPLC 2.3.2 General Morphology of HPLC Stationary Phase Particles 2.4 Normal Phase Liquid Chromatography 2.4.1 Characteristics of Normal Phase Liquid Chromatography 2.4.2 Elution Ability of Mobile Phase 2.4.3 Applications 2.5 Reversed-phase Liquid Chromatography 2.5.1 Stationary Materials for Reversed-phase Liquid Chromatography 2.5.2 Retention Characteristic of Reversed-phase Chromatography 2.5.3 Secondary Chemical Equilibria in the Reversed-phase Chromatography 2.5.4 Applications of Reversed-phase HPLC 2.5.5 Ion-pair Reversed-phase Chromatography 2.6 Ion-exchange Chromatography 2.6.1 Separation Principle of IEC 2.6.2 Stationary Phase Materials of IEC 2.6.3 Retention of Analyses in IEC 2.6.4 Major Factors in the IEC Separation 2.6.5 Detection in IEC 2.6.6 Advantages of IEC 2.6.7 Application 2.7 Size-exclusion Chromatography 2.7.1 Separation Mechanism 2.7.2 Packing Materials for SEC 2.7.3 Applications of SEC 2.8 Affinity Chromatography 2.8.1 Nature of Affinity Interaction 2.8.2 Separation Principle of Affinity Chromatography 2.8.3 Ligand Selection 2.8.4 Selection of Supporting Materials 2.8.5 Preparation of Packing Materials for Affinity Chromatography 2.8.6 Separation by Affinity Chromatography 2.8.7 Application of Affinity Separation Technology 2.9 Thin-layer Chromatography 2.9.1 Stationary Phases Used in TLC 2.9.2 Operation in TLC 2.9.3 Performance Characteristics of TLC 2.9.4 Detection in TLC 2.9.5 Quantitative Analysis 2.9.6 Applications of TLC Analysis 2.10 Detectors in Liquid Chromatography 2.10.1 Bulk Property Detectors 2.10.2 Solute Property Detectors References CHAPTER 3 HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS 3.1 Introduction 3.1.1 History of Development of HPCE 3.1.2 Advantages of HPCE 3.1.3 Development of High Performance Capillary Electrophoresis Instrument and Technology 3.2 CE Instrument and Electroosmotic Flow 3.2.1 Basic Configuration of HPCE Instrument 3.2.2 Electroosmotic Flow (EOF) 3.3 Capillary Zone Electrophoresis 3.3.1 Separation Principle 3.3.2 Electrophoretic Velocity and Mobility 3.3.3 Measurement of Electrophoretic Velocity and Mobility 3.3.4 Factors on Electrophoretic Mobility and Separation 3.3.5 Electrophoretic Separation Parameters 3.3.6 Condition Selection in the CZE 3.4 Micellar Electrokinetic Capillary Chromatography 3.4.1 Formation of Micelle 3.4.2 Characteristics of MEKC 3.4.3 The Parameters and Factors Affecting the Separation 3.4.4 Application of MEKC 3.5 Capillary Isoelectric Focusing 3.5.1 Principles of CIEF 3.5.2 Advantage of CIEF 3 |
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